Sentences with phrase «muscular atrophy»
Muscular atrophy refers to the condition when muscles become weak and shrink due to lack of use or other health issues. It means that the muscles are not being used and therefore they lose strength and size. Full definition
«This is the first study done that identifies a target, JNK3, that's independent of the genetic mutation of spinal muscular atrophy for novel therapeutic development.»
sciencedaily.com
The Boston startup said its deal with the New York - based Spinal Muscular Atrophy Foundation calls for two years of research and development funding from the foundation.
Respiratory muscle function in infants with spinal muscular atrophy type I. Pediatr Pulmonol.
Lagoon also plans to continue raising money for spinal muscular atrophy research, which he's been doing since his daughter's birth.
Researchers have concluded that progressive strength training can counteract age related muscular atrophy.
There she studied the molecular mechanism of Spinal and Bulbar Muscular atrophy using induced pluripotent stem cells.
April 24 - Drugmaker Biogen Inc's quarterly revenue missed analysts» estimates on Tuesday as it had disappointing sales of its promising drug Spinraza to treat spinal muscular atrophy because fewer new patients used the expensive treatment.
This is rarely beneficial and can often induce muscular atrophy due to compromised structural recovery.
And much of the company's fate will rest on Spinraza, a new muscular atrophy drug that comes at a steep list price of $ 750,000 for the first year of treatment.
Arnott agreed to take part to raise money for the Spinal Muscular Atrophy charity.
Nusinersen and similar compounds being developed for spinal muscular atrophy focus on increasing or making more of the SMN gene product that gets converted into usable protein.
«Candidate drug provides benefit in spinal muscular atrophy animal models.»
«Drug for spinal muscular atrophy prompts ethical dilemmas, bioethicists say.»
«Researchers seek biomarker to assess spinal muscular atrophy treatment.»
People with spinal muscular atrophy lack a protein that is required for the motor nerve cells in the spinal cord to function.
In a recent study published in the December 15th issue of Human Molecular Genetics, Dr. Gangwani and his team of researchers at TTUHSC El Paso describe how mice with spinal muscular atrophy saw great improvement when the JNK3 enzyme was genetically inhibited to eliminate its activity.
Spinal muscular atrophy affects between one in 8000 and one in 12,000 infants, and about one in 50 adults are unaffected carriers.
Spinobulbar muscular atrophy, another neurodegenerative disease caused by increased CAG size
The SMA Foundation has worked in partnership with several other Spinal Muscular Atrophy organizations to establish national and international networks of clinics ready for clinical trials.
Spinal muscular atrophy involves wasting of the skeletal muscles and is caused by gradual degeneration of nerve cells in the spinal cord.
Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy Proc Natl Acad Sci U S A. 2013 Jun 11; Authors: Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis - Tsakonas S
2013 May 16; Authors: Kissel JT, Elsheikh B, King WM, Freimer M, Scott CB, Kolb S, Reyna SP, Crawford TO, Simard LR, Krosschell KJ, Acsadi G, Schroth MK, D'Anjou G, Lasalle B, Prior TW, Sorenson S, Maczulski JA, Swoboda KJ, For the Project Cure Spinal Muscular Atrophy Investigators» Network
Spinal muscular atrophy funding peaked this year at $ 5 million, after remaining under $ 3 million for several years.
CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders caused by mutations in genes that affect the normal function of the peripheral nerves.
Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses.
The researchers discovered that regular strength training improved muscle strength, lessened muscular atrophy, and that bones and tendons adapt too.
Selective type II fibre muscular atrophy in patients with osteoarthritis of the hip.
As we know, catabolism and muscular atrophy doesn't really take place until after 24 hours of not eating so fasting for 16 - 20 hours a day is perfectly acceptable and encouraged when trying to lose weight.
New York, NY — December 1, 2006 — The Spinal Muscular Atrophy Foundation announces the addition of Ivan Lieberburg, Ph.D., M.D. and Edward Kaye, M.D. to its Scientific Advisory Board.
Leg muscle function and fatigue during walking in spinal muscular atrophy type 3.
This year, for example, scientists in Germany and at the health institutes showed that valproic acid, an epilepsy drug, could more than double S.M.N. protein levels in cell cultures taken from spinal muscular atrophy patients.
Sarcopenia or age related muscular atrophy can start as early as age 20.
CREBBP has also been associated with Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease, a neurodegenerative disease with progressive degeneration of motor neurons in the brain and spinal cord, Alzheimer's disease and poly glutamine repeat diseases such as Spinal and Bulbar Muscular Atrophy and Huntington's disease.
This can result in various clinical signs including muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, muscular excitation, incoordination and weakness, as well as seizures [2,10,31].
The Spinal Muscular Atrophy Foundation awarded the grant to Curis to identify therapeutic compounds that could be used to treat the neuromuscular disease, which is the leading genetic cause of infant and toddler -LSB-...]
It's aggressively focused on curing spinal muscular atrophy.
Reldesemtiv has been granted orphan drug designation by the FDA for the potential treatment of spinal muscular atrophy.
Beyond Alzheimer's, Genentech is working on other neuroscience programs in multiple sclerosis and rare neurologic conditions like Huntington's and spinal muscular atrophy, at a time when other pharmaceutical companies have largely left the space.
Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis.
SPINRAZA ® (nusinersen) has been approved in global markets for the treatment of spinal muscular atrophy (SMA).
Spinraza, the first Food and Drug Administration - approved treatment for spinal muscular atrophy, had quarterly...
Growing up with spinal muscular atrophy, Maayan Ziv knows firsthand the frustration and challenges that a lack of accessibility can cause.
And, more recently, we witnessed the approval of Spinraza as a treatment for spinal muscular atrophy (SMA) in adults and children this past December.