Sentences with word «mutagenic»

Because males continually produce fresh sperm, the apparent mutagenic effect of air pollution starts to disappear when they begin breathing clean air again.

Gantz and Bier developed a method they call mutagenic chain reaction (MCR) that autocatalytically produces homozygous mutations.

Researchers at Oregon State University have discovered novel compounds produced by certain types of chemical reactions — such as those found in vehicle exhaust or grilling meat — that are hundreds of times more mutagenic than their parent compounds which are known carcinogens.

Smoke from forest fires may contain potent mutagenic compounds that can damage human DNA, according to a controversial new study of fire emissions.

Garlic and flavonoid phytonutrients found in fruits, vegetables, nuts, and grains appear to protect against DNA damage induced by mutagenic chemicals found in cooked meat.

Therefore, our study provides evidence of the existence of additional mutagenic processes in melanoma patients with MC1R variants, which make up about 26 - 40 % of the patient population3.

If the blueprint is damaged, for example due to radiation or mutagenic substances, this can lead to the loss of this stop signal.

She demonstrated how detailed downstream analyses of all mutations present in WGS breast cancers could reveal mutation signatures, imprints left by mutagenic processes that have occurred through cancer development.

These results would indicate that hormones do not have a direct mutagenic effect on mammary cells.

The reason it's been such a long time coming is that research out of Japan in the»90s found that steviosides, the active ingredient in stevia, appeared totally harmless, but in the guts of rats intestinal bacteria transformed steviosides into something called steviol, which is toxic, causing a big spike in mutagenic DNA damage (see the graph in Is Stevia Good For You?).

I can't even imagine how one would do that, especially by human ancestors - eat mutagenic material?

Furthermore, inflammatory cells can release mutagenic chemicals, such as reactive oxygen species, that increase the mutation rates in tumor cells, further accelerating their evolution towards more aggressive growth.

Cancers related to chronic mutagenic exposures, such as lung cancer (tobacco smoke) and cutaneous melanoma (UV radiation), have the highest rates of somatic mutations.

I am also developing a method to distinguish the effect of natural selection from mutagenic recombination.

And, they found that curcumin was «an effective antimutagen against several environmental and standard [mutagenic and cancer - causing substances].»

Excess levels of mutagenic forms of estrogen have been linked to a greater risk of breast cancer, and scientists are studying dietary means of naturally reducing levels of these dangerous estrogens.

This is significant since these estrogens have mutagenic affects «Toxicological and epidemiological studies have indicated that E2 could be categorized as a carcinogen.

The possibilities are pretty much endless, ranging from werewolves through aliens and dinosaurs all the way to mutagenic parasites.

Seventeen of the featured artists are creating new work commissioned by SJMA for the exhibition, in which they will tackle topics that range from the histories of breadmaking to mutagenic foods.

They named it the «mutagenic chain reaction.»

«Radiation - induced mutation breeding is potentially even more mutagenic than GM»?

So we now know that when we eat stevia, mutagenic compounds are produced in our colons and absorbed into our bloodstream.

Hormones do not have any direct mutagenic effect on mammary cells.

«It certainly gives a warning flag that the possibility for mutagenic or carcinogenic compounds exists, but they need to do a lot more work to establish that,» says Propper.

Aloe Vera does not contain any cancer or mutagenic substances.

It manufactures toxic and mutagenic chemicals called macrozamin and cycasin.

In the laboratory, steviol can be converted into a mutagenic compound — if cell DNA becomes mutagenic, cancer may ensue.

The formamide is also one of the substances known as «CMR (carcinogenic and / or mutagenic or toxic to reproduction) for the European Union, as a reproductive toxicant.

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations.

We have developed a method called the mutagenic chain reaction (MCR), which is based on the CRISPR / Cas9 genome - editing system for generating autocatalytic mutations, to produce homozygous loss - of - function mutations.

MN: I think there is a mutagenic element to human activity, but it's difficult to gather proof.

«It looks like it's a very important component of thirdhand smoke, and it is much less studied than NNK and NNN in terms of its mutagenic potential,» he said.

In a method ominously dubbed «mutagenic chain reaction,» the researchers drove a pigmentation trait in lab - grown fruit flies to the next generation with 97 % efficiency.

«This is the very first study to find that thirdhand smoke is mutagenic,» said Lara Gundel, a Berkeley Lab scientist and co-author of the study.

For technical reasons based on how the mutagenic assays are conducted, the researchers said these numbers may actually understate the increase in toxicity — it could be even higher.

«Some of the compounds that we've discovered are far more mutagenic than we previously understood, and may exist in the environment as a result of heavy air pollution from vehicles or some types of food preparation,» said Staci Simonich, a professor of chemistry and toxicology in the OSU College of Agricultural Sciences.

NPAHs based on two nitrogen groups can be 272 to 467 times more mutagenic.

«New compounds discovered that are hundreds of times more mutagenic.»

«That's just not accurate, a very minor percentage of alkaloids are mutagenic,» he says, noting that caffeine and cacao (the key ingredient in chocolate) are also alkaloids.

Propper, emphasising that he is stating his opinion and not that of the CARB, goes on: «The pine needles of Ponderosa pine are toxic to some degree — that's how they defend themselves, with alkaloids — but there isn't anything in this paper to show that they are mutagenic.»

The neurotoxic, immunotoxic and mutagenic effects of this substance have been confirmed in animal models.

Now researchers have found the act of sex between such genetically identical organisms can itself be mutagenic, meaning it can create genetic changes and diversity where it did not previously exist.

The mutational spectra of most lung cancers were characterized by a high proportion of C: G > A: T transversions, compatible with the mutagenic effects of tobacco carcinogens.

In this study, we utilized patterns of mutagenesis known as mutational signatures, which are imprints of the mutagenic processes associated with MMR deficiency, to identify MMR - deficient breast tumors from a whole - genome sequencing dataset comprising a cohort of 640 patients.