Katrin Wiese explains, «
Our mutant Myc turned on genes without a hitch but it had difficulties to turn genes off.
Even with this handicap,
mutant Myc was able to instruct the cells to divide but it could not instruct the cells to die.»
«Tumors become addicted to excessive protein production, and
mutant myc itself seems to depends on it,» Ruggero said.
Not exact matches
Professor Martin Eilers, from University of Wurzburg and his Ph.D student Katrin Wiese had been working with an experimental
mutant version of
Myc, which collaborates with Max but refuses to work with the partner Miz - 1.
«RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals
Myc as a driver of Pten -
mutant metastasis» appears online in Cancer Discovery on January 21, 2014.