Sentences with phrase «mutant cells increased»

DNA content in the mutant cells increased and some of the resulting cell sizes were larger.

Not exact matches

Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

No one knows exactly how this works, but the mutant worms — known as daf - 2 mutants — increase production of enzymes that protect cells from oxidants.

However, this is unlikely given that the frequency of in - frame mutations remained stable over nearly four weeks in culture, that there was no significant increase in cell death between control cultures and those treated with X4 - ZFNs, and that the most common in - frame mutant was not expressed on the cell surface and thus can not maintain functionality.

«In the new study we saw huge increases in the proliferation of the special iNKT cells in TET2 / 3 mutant mice.

Expression of the familial PD - linked A53T or A30P mutant ASs in cell models results in an increased proportion of CTTAS being produced than is the case when expressing the WT protein; consistent with this, a higher proportion of the total soluble AS in human brain tissue with AS neuropathology is CTTAS, and a higher proportion yet of the total AS in insoluble AS deposits.

Testing eight different combinations of the corrective tRNAs, each designed with or without the RP import signal, its modified aminoacyl stem, or the MTS, they found that with the inclusion of all three modifications — and only with their inclusion — expression of their constructs induced a substantial increase in mitochondrially - encoded protein synthesis (6 -8-fold) and respiration (~ 2.5-fold) in mutant cybrid cells.

Moreover, cells expressing the V617F / Y931C double JAK2 mutant showed identical sensitivity to the inhibitors as cells expressing Y931C mutant alone, with a 20 to 50-fold increase in the IC50 (INCB018424 and CMP6, respectively) compared to V658F mutation - positive cells.

In these situations, rather than eliminating the neoplastic clone, deletion of mutant cells can paradoxically lead to their increased turnover.

Together, this new data suggests that the missing endodermal cells observed at the end of gastrulation (Figure 1B) are not due to initial specification or proliferation defects but instead may result from an increase in cell death in toddler mutants during gastrulation.

Thus, lefty mutants have increased Nodal signaling resulting in increased endodermal and mesodermal gene expression and cell number during gastrulation (Meno et al., 1999; Rogers et al., unpublished).

Third, wild - type and toddler mutant embryos were injected at the one cell stage with increasing levels of Nodal mRNA and Nodal target gene expression was measured just prior to gastrulation using qRT - PCR.

Using a mutant version of green fluorescent protein and chromatin modifying agents, recently, in collaboration with Prof. Dénes Dudits (Institute of Plant Biology, BRC, HAS, Szeged), we have achieved significantly increased frequency of TNE on cultured maize cells.