Sentences with phrase «mutant form»

For confirmation, the researchers looked at mutant forms of the protein.

At various points, Kirby will be transformed into a variety of vehicles — similar to his blasphemous mutant forms in Kirby's Epic Yarn — with their own special properties.

This would seem to prevent researchers from making dog «knockouts» lacking a specific gene or engineering dogs that produce mutant forms of a gene.

The trimer - expressing cells even died more quickly than cells expressing mutant forms of SOD1 that are found in severe hereditary ALS cases.

To confirm whether this new enzyme performed the same role as the other xanthophyll enzymes, the researchers inserted the CVDE gene into mutant forms of algae and plants that do not produce zeaxanthin.

Schoolnik's team produced several mutant forms of the bacterium, one of which produced no pili at all and another produced superpili that bound the organisms together even more tightly than those of the normal strain.

In addition, Kuchina and colleagues used biotechnology to engineer mutant forms of B. subtilis in which the two critical genes were located near one another.

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

• KRAS genes drive healthy cell division; mutant forms lead to leukemia and lung, colon, or pancreatic cancers.

Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles.

Lack of ROXY1 activity in the roxy1 mutant leads to a reduced petal initiation, whereas pan mutants form five instead of four petals, indicating opposing effects on promoting petal initiation.

Ware's current goal is to create an optimized mutant form of LIGHT with the strongest ability to drive anti-tumor immunity.

This transition could have involved the co-option of not expression (which is absent from the axochord, see above) given that zebrafish not null mutants form muscle tissue instead of notochord (36).

Both of these Types seem to occur in two forms, a common low to non-dangerous (= low - virulent, avirulent) form, common in cats and a much less common lethal mutant form.

For her latest solo at Kraupa - Tuskany Ziedler, Beijing - based artist Guan Xiao creates mutant forms and dissonant temporalities in sculpture and video that shed light on our present moment.

And it takes on an odd, mutant form in Dredd, where the hero (a joint performance by Karl Urban and his jawline), by design and will, is entirely defined by an unyielding external code.

Right before you are about to experience an in game cut scene (doesn't work on movies of course) push up on D - pad to change into mutant form and then activate the cut scene to view the cut scene in mutant vision.

Mutant forms of Lgl allow cancerous cells to reproduce unchecked.

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

A mutant form of LRRK2, common in Jews of European descent and people from north Africa, is known to be involved in the development of Parkinson's, but exactly how was unclear.

Fruit flies with the mutant form of LRRK2 also had a disrupted microRNA pathway associated with the gene, and accumulated toxic proteins that killed motor - coordinating neurons in the brain.

It is caused by a single gene abnormality which leads to the production of a mutant form of a protein called huntingtin (mHtt).

Whereas mice infected with the regular M3 died within a day, a quarter of animals infected with the mutant form survived.

In HD, an expansion of a trinucleotide repeat sequence in the gene encoding huntingtin protein results in the production of a mutant form of huntingtin that can aggregate and damage cells, particularly neurons in the striatum and cerebral cortex.

Cell assays and animal studies suggest that drugs that restore p53's activity work with not just one mutant form of the protein, but many, says Alan Fersht, a chemist at the University of Cambridge in the United Kingdom.

The researchers found that the 131 G -6-PD-deficient infants had a much higher risk for severe jaundice if they also carried a mutant form of the gene for Gilbert's syndrome.

But the mutant form of the ADAM10 gene did exactly the opposite: It blunted the action of the enzyme, resulting in the production of more of the toxic proteins.

They used mice and cartilage cells in a dish to study one mutant form of IDH that is identified only in cartilage cells.

«Another important finding from this study is that we uncovered a mutant form of NS1 that accelerated lethality in flu - infected mice which was linked to stronger activation of Hedgehog signaling,» said Smelkinson.

In contrast, the mutant forms of FUS / TLS accumulated in the cytoplasm of neurons, a pathology that is similar to that of the gene TAR DNA - binding protein 43 (TDP43), whose mutations also cause ALS.

The persistence of this kind of genetically rooted male stupidity is an evolutionary puzzle, since natural selection seems to have weeded out this mutant form of IGF2R from just about every other species.

«This is a dramatic demonstration that ribozymes may be selective enough to recognize a mutant form of a gene while potentially not interfering at all with the [nonmutant] form,» says microbiologist and molecular geneticist Tom Burke of the University of Vermont in Burlington.

Huntington's disease is caused by a mutant form of a single gene called Huntingtin.

It is used to treat non-small-cell lung cancer (NSCLC), in cases where the cancer cells have a particular (T790M) mutant form of EGFR.

Miller, then - graduate student Sarah DeVos, PhD, and colleagues studied genetically modified mice that produce a mutant form of human tau that easily clumps together.

Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form of Huntingtin, or with a mutant form of Huntingtin that was treated with small amounts of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and RNA out of the nucleus.

Because a particular apoE variant, called apoE4, had previously been shown to be a risk factor for late - onset Alzheimer's, Tanzi and his colleagues reasoned that the mutant form of this other receptor - binding protein, a2M, might be as well.

Working with a non-pathogenic cousin of M. tuberculosis called M. smegmatis, the team used a mutant form of the bacteria that lacked the part of RbpA that interacts with fidaxomicin.

To address this question, the researchers cross-bred SIGMAR1 deficient mice with the other inherited ALS mice which overexpress a mutant form of SOD1 gene.

In studies of cells, the team was surprised to learn that a family of ligands they had never considered as relevant to FOP, called activins, were switching on the mutant form of ACVR1; activins typically curb signaling by the normal receptor.

Huntington's patients have a mutant form of a protein called huntingtin that contains between 36 and 120 repeats of the amino acid glutamine, where unaffected individuals have just a couple dozen repeats.

The researchers also identified a way to remove the problematic GlcNAc sugar so that a mutant form of the bacteria with only rhamnose - containing GAC could be purified and tested as a vaccine antigen.

They analyzed CRYAA and CRYAB and discovered that in one type of hereditary cataract, CRYAB takes on a mutant form with a much higher melting temperature than its normal version.

Gale and his colleagues wanted to find a form of Factor VIIIa protein that would be more stable, and they decided to try to make a mutant form of the protein with sulfur - containing cysteine residues at strategic locations in two of the three chains.

Although the structure of the mutant form of the protein was not investigated, this study provides an excellent platform to build upon and will boost drug development efforts.

They found that their mutant form of Factor VIIIa held together in its three - subunit form and was active much longer than the normal form of the protein.

«Huntington's — an inherited and fatal disorder that leads to problems with muscle coordination, cognition and personality — is characterized by the toxic buildup of a mutant form of the huntingtin protein in the brain,» explained Dr. Finkbeiner, who directs the Taube - Koret Center for Neurodegenerative Disease Research at Gladstone.