Sentences with phrase «mutant gene constructs»

Most notably, the studies are based on transient transfection of wild - type and mutant gene constructs into cultured cells or into zebrafish embryos and are unlikely to reproduce the specific mutant gene dose that is present in heterozygous mutant cells in FOP patients.

Not exact matches

To examine the functional effects of the ACVR1 c. 617G → A; R206H mutation that occurs in classic FOP patients, we compared the activity of wild - type (c. 617G; R206) and mutant (c. 617A; R206H) ACVR1 expression constructs on expression of the BMP pathway transcriptional target gene inhibitors of differentiation 1 (ID1)(29, 30).

C, schematic representation of the wt or mutant RIG - G promoter - luciferase reporter gene constructs.