Sentences with phrase «mutant huntingtin aggregates»
Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.
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The mutant Huntingtin gene is thought to cause toxic levels of protein to aggregate in the brain.