Sentences with phrase «mutant huntingtin causes»

«A long - standing mystery among researchers was how the buildup of this mutant huntingtin caused cells to degrade and die, but previous technology made it virtually impossible to monitor this process at the cellular level.

Not exact matches

In humans, Huntington's is an inherited disease caused by a gene encoding a toxic protein, called mutant huntingtin, which causes brain cells to die.

Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin) that causes brain cells to die.

It is caused by a single gene abnormality which leads to the production of a mutant form of a protein called huntingtin (mHtt).

This abnormal binding causes more VCP accumulation on the mitochondria,» Nerve cells with VCP - mutant huntingtin interacting inside them became dysfunctional and self - destructed.

«The damage caused by the mutant huntingtin protein radiates out through the cell, like a pebble dropped in a pond.

Being able to detect and measure the amount of mutant huntingtin present in the nervous system will be a valuable way of seeing whether the gene - silencing drug is hitting its target and has the intended effect, lowering the amount of disease causing mHTT protein.

«We don't know exactly how the mutant Huntingtin gene causes the disease, so the idea is that targeting the gene expression cuts off the problem at its source — preventing it from ever having the potential to act,» said Dr Isalan.

The mutant Huntingtin gene is thought to cause toxic levels of protein to aggregate in the brain.

Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin or mHTT).

Huntington's is an inherited disease caused by a gene encoding a toxic protein (mutant huntingtin) that causes brain cells to die.

Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin or mHTT) that causes brain cells to die.

While everyone agrees that the mutant huntingtin protein is the main cause of harm in Huntington's disease, some researchers think that huntingtin RNA could be an additional source of damage.

That causes cells to manufacture a harmful protein — mutant huntingtin.

Figuring out how the mutant huntingtin protein causes damage is the central problem of Huntington's disease research.

The huntingtin protein, which in its mutant form causes Huntington's disease, is difficult to study because it forms clumps rather than neat crystals.