Sentences with phrase «mutant mouse lines»

Using this, we have identified abnormalities in these structures among 298 embryos from mutant mouse lines carrying embryonic lethal gene mutations produced for the Deciphering the Mechanisms of Developmental Disorders (DMDD) programme.

Here we show the results of screening 810 mutant mouse lines using an in vivo assay to identify microenvironmental regulators of metastatic colonization.

EMMA comprises over 6000 mutant mouse lines carrying targeted, transgenic, endonuclease - mediated, induced and other types of mutations.

The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES - cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who generated the mouse line, owner of the mouse line)

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

Not exact matches

Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples.

A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

The phenotyping pipeline that will be used within INFRAFRONTIER - I3 builds on the EUMODIC pipeline and uses a cohort of seven female and seven male mutant mice for a comprehensive first - line phenotyping analysis.

Phenotype data from 449 mutant alleles were acquired, representing 320 unique genes, of which half had no previous functional annotation and data from over 27,000 mice were captured, finding that 83 % of the mutant lines are phenodeviant, with 65 % demonstrating pleiotropy.

GMC strategy: To develop and offer a large scale standardised and comprehensive phenotypic analysis of mouse mutants from various sources (e.g. transgenic lines, knockout mice, ENU mutants or endonuclease mediated mutations)

Mouse mutant lines can be tested through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

If a mouse mutant line was provided by selected applicants for a phenotyping project, sharing of the mouse line is also required and facilitated by the INFRAFRONTIER / EMMA repository.

The core services of INFRAFRONTIER comprise the systemic phenotyping of mouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA)(www.infrafrontiermouse mutants in the participating mouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA)(www.infrafrontiermouse clinics, and the archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA)(www.infrafrontiermouse mutant lines by the European Mouse Mutant Archive (EMMA)(www.infrafrontiemutant lines by the European Mouse Mutant Archive (EMMA)(www.infrafrontierMouse Mutant Archive (EMMA)(www.infrafrontieMutant Archive (EMMA)(www.infrafrontier.eu).

As noted in the JAX ® Mice strain data sheets, the best control for a targeted mutant is the 129 strain used to produce the ES cell line from which the mutant was derived (Simpson et al. 1997; Threadgill et al. 1997).

The funded access unit covers the derivation of a single mouse mutant line into a germ - free condition.

The phenotypes were identical among the mutant mice from two independent lines and we did not distinguish our analyses between the two lines.

Note: For live mice from a cryo - preserved line, you are ordering at minimum the Resuscition; a quantity of 1 litter is normal as you will receive the resulting litter with at least one mutant carrier for breeding.

Mutant mouse and cell lines are distributed using the MMRRC Conditions of Use * (COU).

The European Mouse Mutant Cell Repository (EuMMCR) holds and distributes vectors and mutant ES cell lines produced in the EUCOMM and EUCOMMTools consortia representing over 16.800 different Mutant Cell Repository (EuMMCR) holds and distributes vectors and mutant ES cell lines produced in the EUCOMM and EUCOMMTools consortia representing over 16.800 different mutant ES cell lines produced in the EUCOMM and EUCOMMTools consortia representing over 16.800 different genes.

The Mutant Mouse Resource and Research Center (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines wiMouse Resource and Research Center (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines wimouse strains and mouse ES cell lines wimouse ES cell lines with...

The Company develops and brings to market proprietary lines and licensed product, including, Wild Kratts, Teenage Mutant Ninja Turtles ®, Garfield, The Wiggles, Crashlings, My Girl's Dollhouse, Vrüm, WWE ®, Disney Princess ®, Minnie Mouse ®, Marvel ®, Batman ®, Superman ®, Iron Man ®, Sponge Bob ®, Sesame Street, Dora the Explorer ®, and Monster Jam ®.