Sentences with phrase «mutant zebrafish»

Before CRISPR — an acronym for clustered regularly interspaced short palindromic repeats — there were already about 2,000 strains of mutant zebrafish.

In cardiac research, Peterson has used mutant zebrafish to understand how a dozen or so drugs work.

For HHMI researcher Leonard Zon, however, these names describe mutant zebrafish that...

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness.

Not exact matches

Baier plans to use larval stages but he admits it is not clear yet whether the larval zebrafish will react in the same way as the adult mutants.

If you actually read the paper that launched a thousand offbeat tidbits, by one Emmanuel Mignot of Stanford University, you discover that those «mutant» zebrafish with the defective genes were engineered to be mutants, in bulk, purely for the purpose of research.

Homozygous null bmp7 or bmp2b mutant embryos were obtained from crosses between bmp7 or bmp2b heterozygous zebrafish.

Most notably, the studies are based on transient transfection of wild - type and mutant gene constructs into cultured cells or into zebrafish embryos and are unlikely to reproduce the specific mutant gene dose that is present in heterozygous mutant cells in FOP patients.

In transient transgenic reporter studies of zebrafish embryos, the +254 kb element holds up: the wild - type allele had enhancer activity in 41/82 embryos (50 %), whereas the mutant allele had enhancer activity in 3/83 embryos (3.6 %).

Mirror Movement - Like Defects in Startle Behavior of Zebrafish dcc Mutants Are Caused by Aberrant Midline Guidance of Identified Descending Hindbrain Neurons.

Researchers studying the colorfully named zebrafish mutant, mind bomb, have discovered a way to replenish blood cells more quickly after exposure to radiation.

To block all miRNA formation in zebrafish, we generated maternal - zygotic dicer (MZdicer) mutants that disrupt the Dicer ribonuclease III and double - stranded RNA - binding domains.

The big boost to the zebrafish field came when two big genetic screens searching for mutants were carried out in the early 1990s.

Modeling of PRDM16haploinsufficiency and a human truncation mutant in zebrafish resulted in both contractile dysfunction and partial uncoupling of cardiomyocytes, and also revealed evidence of impaired cardiomyocyte proliferative capacity.

This transition could have involved the co-option of not expression (which is absent from the axochord, see above) given that zebrafish not null mutants form muscle tissue instead of notochord (36).

Zebrafish rad51 loss - of - function mutants developed key features of FA, including hypocellular kidney marrow, sensitivity to cross-linking agents, and decreased size.

CRISPR not only allows researchers to create these animals faster and more precisely than before, but also to move beyond a relatively small menagerie of standard model species — fruit flies, mice, zebrafish — to create a Noah's ark of mutant dogs, pigs, primates and more.