Sentences with phrase «mutated alleles»

Multiplex PCR was designed to amplify the normal and mutated alleles of canine ADAM9 (Table 7, Figure 4A, B).

The dog's color can vary greatly with different mutated alleles on other genes.

(B) DNA sequence of mutated alleles from MSTN - mutant colonies.

Interallelic complementation is defined as the ability of two differentially mutated alleles to function better together than either can on its own.

The woman's unborn child inherits one allele from its mother and one from its father, which gives it a 25 percent chance of getting two healthy alleles; a 50 percent chance of one faulty allele and one healthy; and a 25 percent chance of getting two mutated alleles that together would cause it to develop beta - thalassaemia, a potentially fatal blood disorder caused by low oxygen uptake.

But to work out whether the mother's mutation had also made it into the fetus's DNA, Lo's team developed a way to count how many times each of the mother's healthy and mutated alleles appeared in the blood sample.

MCR uses the initial mutated allele to cause a mutation in the allele on the opposing chromosome and thus the homozygosity of the trait.

NCL is an autosomal recessive inherited disease i.e. the disease develops in dogs, who inherit the mutated allele from both parents.

The carriers of the mutated allele (heterozygotes) are clinically healthy, but pass the mutation on to their offsprings.

The affected dogs (A) are homozygous for the dodecamer repeat expansion mutation with multiple dodecamer repeats, carrier (C) dogs have the normal and mutated allele and clear dogs (WT) have three copies of the repeat [8]

Not exact matches

Because alleles found to be mutated only once in 5,338 tumors rendered cells tumorigenic, these observations underscore the value of integrating genomic information with functional studies.

To determine why previously described mutated EYA4 alleles cause SNHL without heart disease, we examined biochemical interactions of mutant Eya4 peptides.

When the TSM is mutated with, for example, a G44S allele, the idea is that Sgo1p can no longer bind causing chromosomes to sometimes segregate incorrectly.

Previous work had shown that mutating Gcn5p can partially rescue the effects of the G44S allele.

Then, using the CRISPR / Cas9 endonuclease system and a guide RNA targeting the region containing the SCD mutation, the group successfully corrected one mutated HBB allele with no undesired insertions of the donor vector seen elsewhere in the genome.

BRCA1 is a classical tumor suppressor and it is inactivated only when both gene copies / alleles are mutated (one by germ - line mutation and the other by somatic mutation).

This mutation is recessive so two copies of the mutated gene (or «d» allele) are needed to produce the dilute coat color.