The findings suggested that
a mutated gene in this region was responsible for many cases of both conditions, but scientists did not pinpoint a specific gene.
Not exact matches
Twin
genes or duplicated regulatory
regions result, and although one
in the pair usually has to keep doing its original job, the other is free to
mutate and take on new roles that can enhance an organism's survival.
The researchers then analyzed another 147 colorectal cancer cell lines
in the same way for kinase - domain mutations
in these
genes, and then sequenced the entire coding
region of all kinases that were
mutated,
in all discovering 46 new mutations.
However,
in the deleted chromosome
region, BECN1 is adjacent to BRCA1 (breast cancer 1, early onset), which is a breast cancer tumor suppressor
gene frequently
mutated in familial breast and ovarian cancers.