Researchers at SciLifeLab have shown that a high - throughput method using microfluidic droplet sorting of
mutated yeast cells can be used to improve the production of industrial enzymes.
Then they expose
these mutated yeast cells to a whole range of chemical compounds used in cancer therapy to find which ones will kill them.
Not exact matches
And researchers at the «Seattle project», an effort funded by the National Cancer Institute to find new anticancer drugs, are
mutating genes in
yeast cells — such as the ATM gene or the mismatch repair genes — that often lead to cancer in humans.
Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of
yeast cells to camptothecin and that inactivation of this pathway by
mutating H4 K16 or the genes SIR1 - 4 suppresses much of the hypersensitivity of tof1 ∆ strains towards this agent.