Mutation analysis refers to a process of examining tiny changes or "mutations" in something, like computer code or DNA. It helps scientists and programmers find and fix errors or bugs by deliberately introducing these mutations and seeing how they affect the system. By doing this, they can identify potential weaknesses or problems and make improvements to ensure better performance and reliability.
Full definition
«We also need to integrate PIK3CA
mutation analysis of breast tumors into routine practice so that we can ensure women receive the most appropriate neoadjuvant therapy for their tumor type.»
While several techniques are currently available to assess EGFR mutation status, these methods require tumor biopsies and can often fail or have poor reproducibility due to insufficient material
for mutation analysis.
«As there are no published guidelines for the use of ctDNA for EGFR
mutation analysis in the absence of tumor tissue, these results may help address this current unmet need.»
Methodological aspects of these analyses will be discussed as well as comparisons
with mutation analyses in plasma.
Synonymous / nonsynonymous
substitution mutation analyses revealed that the majority of nucleotide mutations yielded synonymous amino acids, indicating the presence of purifying selection pressure across the polyprotein with pockets of positive selection also being detected.