With that in mind, the Penn Vet team chose to examine two of their well - established canine models of RP, which recapitulate many features of the human diseases, each
involving mutations in different genes.
Do the same genetic mutations underlie the emergence of these traits in both the Asian and African domestication events, or did domestication result from different mutations in the same genes, or even
from mutations in different genes?
For extended modules, many different combinations of perturbed genes could incapacitate the module, as a result of
which mutations in different genes will appear to lead to the same phenotype (e.g., hypertrophic cardiomyopathy).
Maxson, who is co-mentored on this project by Dr. Jerald Radich and Dr. Soheil Meshinchi, will receive $ 100,000 over a two - year period to study
how mutations in different genes work together to cause childhood leukemia.
If a person who has such a mutation is well, he or she may carry
a mutation in a different gene that compensates for, or buffers, the harmful gene's effect.