Sentences with phrase «mutations by homologous recombination»
For more information: Cell Research Authors: Mo Li, Keiichiro Suzuki, Jing Qu, Preeti Saini, Ilir Dubova, Fei Yi, Jungmin Lee, Ignacio Sancho - Martinez, Guang - Hui Liu and Juan Carlos Izpisua Belmonte Efficient correction of hemoglobinopathy - causing mutations by homologous recombination in integration - free patient iPSCs
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The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse line ② or from genetically modified mouse embryos with two aims:
Approximately 20 % of metastatic prostate cancers harbor mutations in genes required for DNA repair by homologous recombination repair (HRR) such as BRCA2.
One of them states that homologous meiotic recombination increases the efficiency of natural selection by alleviating interference between linked sites, thereby facilitating adaptive evolution and the purging of deleterious mutations [7]--[11].