Sentences with phrase «myelin basic protein»

Host: Dr. Alex MacKay Speaker: Dr. George Harauz, Univ. of Guelph Title: Myel - Stones or The Executive Roles of Myelin Basic Protein in Myelin Assembly and Destabilization in Multiple Sclerosis

Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.

The researchers used a virus called a retrovirus to shuttle IL - 4 genes — plus a «marker» to highlight when the genes are expressed — into a special line of mouse TH1 cells known to target myelin basic protein, the protein at the heart of EAE and MS.. By looking for the marker, the researchers could pick out the cells making IL - 4, and they then used standard cloning techniques to mass - produce them.

The researchers tested these cells on a batch of mice that had been injected with myelin basic protein, which triggers the autoimmune response and causes EAE symptoms to occur in about 2 weeks.

«Multiple sclerosis affects millions of people worldwide,» says the study's lead author, Iftach Shaked, Ph.D., a postdoctoral researcher in the laboratory of LJI professor Klaus Ley, Ph.D. «But what's really puzzling is that we all have autoimmune T cells that recognize myelin basic protein but normally they do not infiltrate the central nervous system and cause disease.»

Noting that myelin basic protein (MBP) has been shown to degrade Aβ chains, the team decided to couple it with CTB to see if MBP would be permitted to cross.

Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein - reactive CD4 + T cells compared.

GAD, myelin basic protein, asialoganglioside, alpha and beta tubulin, cerebellar, synapsin: Neurological autoimmunity