Sentences with word «myeloid»

Her thesis was entitled «Function and inhibition of BRD9 in acute myeloid leukemia cells.»

«Vitamin C may boost effectiveness of acute myeloid leukemia treatment.»

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

This class of drugs has revolutionized the treatment of chronic myeloid leukemia with the game - changing therapy Gleevec, and also is of great benefit in several other forms of cancer.

Locafaro G *, Andolfi G *, Russo F, Camisa B, Ciceri F, Bondanza A, Roncarolo MG *, Gregori S. HLA class I - dependent targeting of myeloid leukemia by IL -10-engineered human CD4 + Tr1 cells.

Bornhäuser M, Kienast J, Trenschel R, et al Reduced - intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open - label randomised phase 3 trial.

In hematopoietic stem / progenitor cells, ANG induces processing of a specific type of RNA (tiRNA) that is quiescence - related whereas in myeloid progenitor cells, ANG induces processing of a specific type of RNA (rRNA) that is proliferation related.

His lab has made contributions in the area of tumor induced immunosuppression of dendritic cells, characterization of human myeloid derived suppressor cells, and the development of novel adjuvants for cancer vaccines.

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

Working in mice, Norbury's team used several methods to deplete different types of innate immune cells — collectively known as myeloid cells — at the three checkpoints before infecting the rodents with poxvirus.

In the Nature Medicine paper, titled, Bone marrow - derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease, the suPAR researchers suggested that their discovery and their investigative approach owed much to the work of other investigators and might prove useful for researchers investigating other diseases that appear to arise spontaneously in certain individuals for no discernible reason.

In mice implanted with human myeloid leukemia tumors, RHT greatly inhibited the tumors» growth and suppressed glucose uptake, similar to the effects seen in vitro.

One of these escape mechanisms involves a type of immune cell called myeloid - derived suppressor cells (MDSCs).

«We have seen SF3B1 mutation in chronic lymphocytic leukemia and in myeloid dysplastic disorders, and now we show its importance in mucosal melanoma,» says Aik Choon Tan, PhD, investigator at the CU Cancer Center and associate professor of Bioinformatics at the CU School of Medicine.

His team studies blood cancers with a particular focus on myeloid leukaemias their pathogenesis, clonal evolution and the development of new anti-leukaemia treatments.

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.

Unexpectedly, X-ADC treatment was > 40-fold more cytotoxic to the normal myeloid progenitors than IMGN632 (median IC90 values of 45 pM vs 1900 pM, respectively, in matched samples).

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

The findings, published in the Proceedings of the National Academy of Sciences, describe how myeloid differentiation factor (MyD88), a protein that plays a major role in mediating host defense response against invading pathogens, is tightly regulated to prevent uncontrolled inflammation.

Deciphering the role in cancer of «non-conventional» T cells that recognize lipid antigens presented by CD1 molecules, non-polymorphic MHC - I - related molecules expressed by mature myeloid and B cells.

«Since patients with many types of cancer have elevated levels of myeloisd cells in their blood, it's possible that other tumors could have a similar interaction with bone to increase myeloid cell production.»

A combination of the FLT3 kinase inhibitor quizartinib with 5 - azacitidine or low - dose cytarabine is active in patients with FLT3 - ITD mutated myeloid leukemias, according to a new study.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

One factor that could contribute to this trend is that blood stem cells from older donors are more prone to inflammation, produce more myeloid cells and fewer lymphocytes, and are more likely to be affected by clonal hematopoiesis, a mutation of blood cells that can increase the risk of blood cancer and overall mortality.

He believes the researchers and labs collaborating on the project are particularly well suited to take on the challenge, bringing to bear expertise in organic and medicinal chemistry (Fasan), drug delivery technologies (Benoit), and the physiopathology of bone marrow during myeloid malignancy (Frisch).

5) Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

A National Cancer Institute long - termstudy, involving25, 619 industrial workers in 10 factories that produced or used formaldehyde, found an increased risk of death due to leukemia, particularly myeloid leukemia, and higher rates of nasal - pharynx cancer.Further examination of the same workers, with ten more years of data, continued to show a possible link to leukemia, as well as lymphoma and multiple myeloma, amongthosewiththe highest exposures.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

First the study team generated iPSCs from two children with JMML, and then manipulated the iPSCs in cell cultures to produce myeloid cells that multiplied uncontrollably, much as the original JMML cells do.

Recent research has suggested that tumor - infiltrating myeloid cells are initially produced in the bone marrow.

Mikala Egeblad Tumor microenvironment; intravital imaging; tumor - associated myeloid cells; breast cancer; pancreatic cancer; chemoresistance; metastasis

The biotech received Food and Drug Administration (FDA) approval for its drug to treat the rare blood cancer acute myeloid lymphoma (AML), which will be marketed as Idhifa, on Tuesday.

One type of cell, the polymorphonuclear myeloid - derived suppressor cell (PMN - MDSC), was present exclusively in the induced tumors.

This research comes from the same group that found ONA suppressed pro-tumor activation of host myeloid cells.

With the ultimate goal of improving patients» quality of life, we hope that modulating myeloid pathways will overcome some of the limitations of current treatment options.»

We have started to study the complexity of myeloid responses to cancer and to identify molecular and cellular components that promote the disease.

They used immortalized myeloid precursor cells — so - called ERHoxb8 cells — which multiply almost endlessly in a test tube and, under certain conditions, can develop into immune cells.

When the researchers mimicked a systemic infection in mice, animals deficient in Del - 1 were slower to begin making myeloid cells again compared to those with normal Del - 1 levels.

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

The absence of IKKß in myeloid blunted genes that normally produce pro-inflammatory molecules, including those that aggravate colitis.