Sentences with phrase «myeloid progenitor»

Their system was based on earlier studies in which Singh and his colleagues identified a transcription factor called PU.1 as a central genetic switch that triggers development of myeloid progenitor cells.

Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl - 2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells.

A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.

In the paper, the researchers show for the first time that ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells that give rise to mature myeloid cells.

«We knew that ANG was involved in promoting cell growth so it was not unexpected to find that ANG stimulates proliferation of myeloid progenitor cells,» said Guo - fu Hu, PhD, Investigator in the Molecular Oncology Research Institute at Tufts Medical Center, and the paper's senior author.

They demonstrated how ANG stimulates proliferation of myeloid progenitor cells.

They also found that 1,4 - BQ was more toxic to HSCs, myeloid progenitors (which give rise to red blood cells and platelets, among others) and B cell lymphoid progenitors than it was to T cell lymphoid progenitors.

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

Although both cell types come from cells known as myeloid progenitors, each type relies on its own set of functionally active genes to carry out its particular role in fighting infection.

BCR / ABL expression of myeloid progenitors increases beta1 - integrin mediated adhesion to stromal cells.

HSCs contain self - renewal capacity and apparently give rise to multipotent progenitors these cells further give rise to oligopotent progenitors which are Common Lymphoid Progenitors (CLPs) and Common Myeloid Progenitors (CMPs).

Both come from cells known as myeloid progenitors.

Unexpectedly, X-ADC treatment was > 40-fold more cytotoxic to the normal myeloid progenitors than IMGN632 (median IC90 values of 45 pM vs 1900 pM, respectively, in matched samples).

However, exposure to X-ADC, but not IMGN632, resulted in robust caspase 3 activation in the late myeloid progenitors (CD34 + CD38 + CD45med).

On average, in comparison with GO, IMGN632 was 70-fold more cytotoxic to AML progenitors and only fivefold more cytotoxic to normal myeloid progenitors.

Not exact matches

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

Rac2 - MRC - cIII — generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.

Notch - mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.

It was heterozygous in most patients, homozygous in a subset as a result of mitotic recombination, and arose in a multipotent progenitor capable of giving rise to erythroid and myeloid cells.

Additional in vitro and in vivo studies are needed to determine the cause of the specificity of JAK2V617F for myeloid diseases, as second mutations, host modifiers, differential cytokine receptor expression, and other factors may influence the ultimate phenotype of hematopoietic progenitors that acquire the JAK2V617F mutation.