Sentences with phrase «myeloma affects»

Diagnostic testing confirmed the diagnosis of multiple myeloma affecting her liver, spleen and bone marrow.

Not exact matches

Multiple myeloma is a cancer that affects plasma cells.

«One - size treatment for blood cancer probably doesn't fit all, researchers say: Most multiple myeloma studies involve people of European descent, but the disease is more likely to affect African - Americans.»

That trend is problematic considering that African - Americans — the most at - risk population for multiple myeloma — have different genetics that can affect how this type of cancer progresses and what kind of targeted therapies are most effective, said Zarko Manojlovic, lead author of the study.

Researchers at MIT have now shown that they can use a new type of measurement to predict how drugs will affect cancer cells taken from multiple - myeloma patients.

In the 1990s the U.S. Food and Drug Administration approved its use in the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosy.

Do Plasma Cells Affect Hemoglobin and Red Blood Cell Counts in Patients With and Without Myeloma?

A study led by Helena Jernberg Wiklund, Uppsala University / SciLifeLab, shows how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Each donation helps accelerate finding a cure for leukemia, lymphoma and myeloma, blood cancers which affect an estimated 1,290,773 Americans.

However, given that these diseases affect many organs of the body and Gaucher in particular has a high incidence of certain cancers, including myeloma, I would suggest that eating the most healthy diet for general health (whole food plant based; scientifically proven) would also be a good idea in these diseases (although I have not seen any studies that say this).

Multiple myeloma is a rare, malignant plasma cell cancer affecting the bone marrow and other blood producing organs.

In multiple myeloma, this M component is found in circulation in the blood and sometimes different organs or bones of the body are also affected.