Sentences with phrase «myeloma as»

Dr Daniel Tennant, who led the research at the University of Birmingham, said, «Our findings show that very few changes are required for a MGUS patient to progress to myeloma as we now know virtually all patients with myeloma evolve from MGUS.

A new study published online by JAMA Oncology examines the assessment of minimal residual disease in patients newly treated for multiple myeloma as a factor in survival outcomes.

«Based on our finding that being overweight or obese is a risk factor for multiple myeloma in MGUS patients, and since extra weight is a modifiable risk factor, we hope that our results will encourage intervention strategies to prevent the progression of this condition to multiple myeloma as soon as MGUS is diagnosed,» Chang said.

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Not exact matches

THE PATIENT AS INNOVATOR With Deborah Brooks of The Michael J. Fox Foundation for Parkinson's Research; Kathy Giusti of the Multiple Myeloma Research Foundation & Consortium; Sean Lane of Crosschx; Claudia Williams of the White House Office of Science and Technology Policy; Rik Kirkland, of McKinsey & Co. — Report by Kia Kokalitcheva — Video: Patients Should Get Access to Their Health Data

Participants included CEOs Jonathan Bush of Athenahealth, Ron Gutman of HealthTap, Dr. Clifford Hudis of the American Society of Clinical Oncology, Dr. Vivian Lee of University of Utah Health Care, VitalConnect CEO Nersi Nazari, James Park of Fitbit, and Andrew Witty of GSK, as well as President of Flex Health Solutions John Carlson, Multiple Myeloma Research Foundation Founder Kathy Giusti, Dr. Sanjay Gupta, Arianna Huffington, Andreessen Horowitz General Partner Vijay Pande, Parker Foundation President Sean Parker, Women's Alzheimer's Movement Founder Maria Shriver, and White House Cancer Moonshot Task Force Executive Director Greg Simon.

So far, its trials have shown it can improve outcomes when used alongside other multiple myeloma drugs and that could offer it some insulation if the market gets disrupted by new treatment approaches, such as gene therapy.

Second, Darzalex secured an important FDA label expansion last year for its use as a second - line multiple myeloma treatment rather than only as a third - line therapy.

In July the FDA approved Onyx's Kyprolis as a treatment for multiple myeloma, a type of blood cancer.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

A National Cancer Institute long - termstudy, involving25, 619 industrial workers in 10 factories that produced or used formaldehyde, found an increased risk of death due to leukemia, particularly myeloid leukemia, and higher rates of nasal - pharynx cancer.Further examination of the same workers, with ten more years of data, continued to show a possible link to leukemia, as well as lymphoma and multiple myeloma, amongthosewiththe highest exposures.

To unravel exactly how ADAR1 is connected to disease severity at a molecular level, the researchers transferred multiple myeloma patient tissue to mice, creating what's known as a xenograft or «humanized» model.

In our study, as BMI increased, we started seeing an increase in the ability of multiple myeloma cells to adhere, which causes the cancer to better anchor,» DeCicco - Skinner explained.

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

As a patient's BMI increases, fat cells communicate with multiple myeloma cells, researchers found.

In the multiple myeloma study, normal weight is defined as a BMI of no more than 25 kg / m2, and morbidly obese is in the range of 35 to 40 kg / m2.

«As body mass index increases, so does spread of multiple myeloma.»

These studies enrolled a total of 12,361 patients diagnosed with a variety of cancers, including lung, breast, skin, and prostate, as well as blood cancers such as leukemia, lymphoma, and myeloma.

Adults with a history of obesity are twice as likely to develop multiple myeloma.

«But our findings show that obesity can now be defined as a risk factor for developing multiple myeloma through this condition,» said the study's first author, Su - Hsin Chang, PhD, an assistant professor of surgery in the Division of Public Health Sciences at Washington University.

Patients with multiple myeloma (MM) appear to have better survival if they are found to have monoclonal gammopathy of undetermined significance (MGUS) first, the state that precedes MM and which is typically diagnosed as part of a medical workup for another reason, according to a study published online by JAMA Oncology.

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

A study that used stored blood samples from U.S. Air Force personnel who conducted aerial herbicide spray missions of Agent Orange during the Vietnam war found a more than 2-fold increased risk of the precursor to multiple myeloma known as monoclonal gammopathy of undetermined significance (MGUS), according to an article published online by JAMA Oncology.

The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of cell suicide known as apoptosis when exposed to agents that induced ER stress.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

The findings are particularly noteworthy because drugs that act on the newly discovered target, a protein known as PIM1, are already in clinical trials for leukemia and multiple myeloma.

Initial treatment for most multiple myeloma patients includes a class of drugs (Revlimid or Pomalyst) broadly known as immune modulators.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania.

«This study presents a novel strategy for treating multiple myeloma, and we hope to bring it to patients as part of a phase I clinical trial as soon as possible,» Hofmeister says.

A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise.

As an organization of physicians and scientists who care for desperately ill patients, including those with blood cancers such as leukemia, lymphoma, and myeloma, the American Society of Hematology (ASH) is supportive of efforts to provide insurance parity for all approved evidence - based cancer treatmentAs an organization of physicians and scientists who care for desperately ill patients, including those with blood cancers such as leukemia, lymphoma, and myeloma, the American Society of Hematology (ASH) is supportive of efforts to provide insurance parity for all approved evidence - based cancer treatmentas leukemia, lymphoma, and myeloma, the American Society of Hematology (ASH) is supportive of efforts to provide insurance parity for all approved evidence - based cancer treatments.

Richard Vague, the event's honorary chair, took the podium to acknowledge the vast achievements of the ACC, as did Lori Alf, a multiple myeloma patient of Edward Stadtmauer, MD, chief of Hematologic Malignancies, whose cancer is in remission after receiving chimeric antigen receptor (CAR) therapy.

The company is developing CAR T - cell immunotherapies for multiple myeloma, prostate and other cancer types, as well as gene therapies for orphan diseases.

Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

Cancers of the breast, prostate, colorectal system, liver and kidney as well as multiple myeloma, a cancer of the plasma cells that make antibodies to fight viruses and bacteria, strike earlier, deadlier and more often in some racial and ethnic groups, the National Cancer Institute has shown.

Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.

As Director of the Hematologic Malignancies / Blood and Marrow Transplantation Program, Dr. Collins is proud that UT Southwestern offers the best care in the area for patients with leukemia, lymphoma, and myelomas.

These diseases include neurodegenerative conditions, such as Alzheimer's disease (AD), Parkinson's disease (PD), tauopathies, prion protein diseases, as well as peripheral amyloidoses, such as immunoglobulin light chain amyloidosis caused by myeloma.

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antiMyeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antimyeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antimyeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antibodies.

The new immune system that grows from the donor stem cells can recognize myeloma cells as «foreign» and kill them, which is known as the «graft - vs - myeloma» effect.

They fused mouse B cells — antibody - producing cells of the immune system — with human myeloma (also known as B cell cancer) cell lines in a new technique called hybridoma technology.

Many people suffering with cancer and diseases associated with immune dysfunction, such as lymphoma, leukemia, multiple myeloma, solid tumors, recurrent infections, neurodegenerative disorders and other chronic diseases, have turned to the Maharaj Institute in the hope of finding a more favorable prognosis and better quality of life.

As the number of multiple myeloma cells increases, more antibodies are made.

As a new member of the elite Multiple Myeloma Research Foundation, we have access to even more new treatments earlier than other facilities, and we are supporting the continued advancement of myeloma theMyeloma Research Foundation, we have access to even more new treatments earlier than other facilities, and we are supporting the continued advancement of myeloma themyeloma therapies.

MGUS can also become cancer, such as multiple myeloma, lymphoplasmacytic lymphoma, or chronic lymphocytic leukemia.

No Place Like Home Rebecca Zoltoski was the first patient at the University of Chicago Medicine to undergo a blood and bone marrow stem cell transplant as an outpatient for her multiple myeloma.

A study led by Helena Jernberg Wiklund, Uppsala University / SciLifeLab, shows how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease.

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antiMyeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antimyeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antimyeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antibodies.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.