Not exact matches
They also determined that blocking the enzyme reduces multiple
myeloma regeneration in experimental models derived
from patient cancer
cells.
The new findings build on prior research
from the Dhodapkar lab demonstrating that
patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing
myeloma; and the discovery of a subset of lipid - reactive immune
cells, called type II NKT - TFH, that promote the development of plasma
cells.
Fat
cells cultured
from the body mass index of a morbidly obese
patient cause multiple
myeloma cells to anchor to a much greater extent than normal
cells and produce a significantly larger number of blood vessels to sustain the cancer
cells.
In humans, a comparison of bone marrow
from 14 normal bone marrow donors, 35 multiple
myeloma patients and 11
patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple
myeloma cells.
Whether investigating fat
cells, immunotherapy or use of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a select number of
patients suffering
from three types of cancers, including multiple
myeloma, approaches beyond attacking cancer
cells are needed in the fight against many cancers.
Researchers at MIT have now shown that they can use a new type of measurement to predict how drugs will affect cancer
cells taken
from multiple -
myeloma patients.
Results
from a clinical trial investigating a new T
cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer
cells demonstrated a clinical response in 80 percent of multiple
myeloma patients with advanced disease after undergoing autologous stem
cell transplants (ASCT).