As the number of multiple
myeloma cells increases, more antibodies are made.
Not exact matches
The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant
increased risk for developing
myeloma; and the discovery of a subset of lipid - reactive immune
cells, called type II NKT - TFH, that promote the development of plasma
cells.
In our study, as BMI
increased, we started seeing an
increase in the ability of multiple
myeloma cells to adhere, which causes the cancer to better anchor,» DeCicco - Skinner explained.
As a patient's BMI
increases, fat
cells communicate with multiple
myeloma cells, researchers found.
Being overweight or obese has been known to
increase the risk of multiple
myeloma, a cancer of the plasma
cells in the blood and bone marrow that develops more often after age 60.
The researchers grew the modified
cells in the lab to
increase their numbers and then injected them into an animal model where they again killed human
myeloma cells.