Sentences with phrase «myeloma tumors»
Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.
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The indication now covers patients with bone metastases from solid tumors and those with multiple myeloma.
«This approval will open the floodgates for these kinds of therapy to be used in many different leukemias, lymphomas, solid tumors, myelomas,» Dr. Prakash Satwani, a pediatric hematologist - oncologist at Columbia University Medical Center, told Business Insider.
Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.
Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.
«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Health.
Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.
In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease spread.
«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.
An international team of researchers has identified eight additional types of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type of brain tumor), thyroid cancer and the blood cancer multiple myeloma.
This gene is known to be highly active in multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety of tumors.
The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.
«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.
A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen
Multiple myeloma is a cancer of plasma cells in the blood that causes tumor growths in bone marrow.
«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical Myeloma Center, and the R.J. Corman professor at Harvard Medical School.
«Therapy shrinks tumors in patients with multiple myeloma.»
Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.
They then compared the pattern of gene abnormalities in the initial myeloma tissue and the metastatic tumors.
Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.
Many people suffering with cancer and diseases associated with immune dysfunction, such as lymphoma, leukemia, multiple myeloma, solid tumors, recurrent infections, neurodegenerative disorders and other chronic diseases, have turned to the Maharaj Institute in the hope of finding a more favorable prognosis and better quality of life.
Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body.
Two genes were already recurrently mutated in the 7 WGS cases: RUNX1, a known myeloid tumor suppressor, and UMODL1, for which mutations were recently reported in multiple myeloma and ovarian cancer.
Multiple myeloma cells are abnormal plasma cells (a type of white blood cell) that build up in the bone marrow and form tumors in many bones of the body.
[i] Gutterman JU, Blumenschein GR, Alexanian R, Yap HY, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S. Leukocyte interferon - induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma.
12 Scientific Sessions Radiochemistry: Imaging of Cancer Other Tumors Basic Science Summary Session One Myeloma and Other Marrow Disorders Radiopharmacy: Quality Control and Validation Radiotherapy and Monitoring Therapy Basic Science Summary Session Two Pre-Clinical Systems Breast Cancer Prostate I: Initial Staging Quantification and Methodology of Oncology Studies Novel Radiochemistry: Radiometals
In addition, a growing number of immunotherapy clinical trials are in place to test this groundbreaking approach on other cancers like lymphoma, multiple myeloma, and for solid tumors, through trials in glioblastoma, mesothelioma, and ovarian and pancreatic cancer.
His paradigm for identifying and validating targets in the tumor cell and its milieu has transformed myeloma therapy and markedly improved patient outcome.
Other bone tumors include chondrosarcoma, fibrosarcoma, hemangiosarcoma, liposarcoma, histiocytic sarcoma, multiple myeloma, and metastatic tumors.
Plasma cell tumors of the bone (multiple myeloma) cause pain and lameness.
In cases of multiple myeloma with bone involvement, blood tests can help to indicate the nature of the tumor.
She has published journal articles and book chapters on topics including canine osteosarcoma, canine and feline liver tumors, and canine and feline plasma cell cancer / multiple myeloma.
Incidentally, the word myeloma is derived from two parts: myelo from the Greek word muelos meaning marrow, and oma, a Greek suffix commonly used to denote a tumor.
Description — Multiple myeloma accounts for less than 1 % of all neoplasms in animals, but among hematopoietic, primary and secondary tumors it consists of 8 % and 3.6 % respectively.
The cause of many of these tumors such as «multiple myeloma» is still unknown but genetic predisposition, viral infection, chronic antigenic stimulation and exposure to environmental carcinogenic substances are all thought to contribute.
Other bone tumors include chondrosarcoma, fibrosarcoma, hemangiosarcoma, liposarcoma, multiple myeloma, and metastatic bone tumors.