Sentences with phrase «myeloproliferative disorders»
"Myeloproliferative disorders" refers to a group of conditions where there is an overproduction of certain types of blood cells in the bone marrow. This can cause an imbalance in the blood cell counts, leading to various health problems. Full definition
«We know people with myeloproliferative disorders, such as essential thrombocythemia, produce too many megakaryocytes and platelets,» he said.
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Through experiments in cell lines, primary patient samples and animal models, the research team found that SYK and FLT3 - ITD's interactions are a key ingredient in the progression of myeloproliferative disorder, a related blood cell disorder, into AML.
«We think this study now provides a comprehensive model of how thrombopoietin controls platelet production, and perhaps gives some insight into the biology and mechanism behind specific myeloproliferative disorders,» Dr Ng said.
«Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders.»
Background: Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis.
4/7/2008 From Bench to Bedside in One Year: Stem Cell Research Leads to Potential New Therapy for Rare Blood Disorder A unique partnership between industry and academia has led to human clinical trials of a new drug for a rare class of blood diseases called myeloproliferative disorders (MPD), which are all driven by the same genetic mutation and can evolve into leuk... More...
Interpretation: A single acquired mutation of JAK2 was noted in more than half of patients with a myeloproliferative disorder.
We investigated the role of the cytoplasmic tyrosine kinase JAK2 in patients with a myeloproliferative disorder.
Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho - myeloproliferative disorders and disseminated intravascular coagulation.
Constitutive activation of tyrosine kinases by chromosomal translocation, 1 interstitial deletion, 2 internal tandem duplication, 3 and amino acid substitution4 have been observed in hematopoietic malignancies including acute myeloid leukemia (AML) and myeloproliferative disorders (MPDs).
You may also hear doctors call them MPN or myeloproliferative disorders (MPD).
Diseases that involve the bone marrow (myeloproliferative disorders) can also be responsible as will any other illness that causes low thrombocyte (platelet) numbers.