These compounds may
cause myelosuppression (decreased bone marrow function); therefore, a complete blood count must be carefully monitored for cytopenia (reduced cell numbers) during therapy.
Other serious AEs include infusion - related reactions,
myelosuppression, and QT interval prolongation.
*** a common side effect researchers worked to reduce was
myelosuppression - decreased bone marrow activity which can lead to immunosuppression, infection and bleeding.
Paclitaxel (Taxol ®) is a widely - used anticancer agent for treatment of ovarian, breast, lung, head, and neck cancer with two serious side effects:
myelosuppression and peripheral sensory neurotoxicity which limits its use in high / cumulative doses or in combination with other anticancer agents.