It has been suggested that women with PCOS have a problem converting myo into DCI (
myo inositol gets converted into DCI when needed to maintain a 40:1 ratio in tissues).
The results showed that the combined treatment of
myo inositol and melatonin seen in Group A had an increased number of mature oocytes obtained (48.2 %) compared with group B (35.0 %) and group C (38.2 %).
I have 1000 mg
myo inositol pills and I'm trying to figure out what the difference between all the other inositol supplements are.
Typical dosage of Ovasitol is 2 packets each day (4 grams
myo inositol total) in two divided doses.
Ive always been irregular and never know if or when I ovulate so not only am I wanting to take
myo inositol for that but to lose weight.
Hi, I am 47 I was diagnosed with PCOS via ultrasound at 27 years old I had the typical strand of pearls (pcos) ovaries and I was not having cycles at all, But I started having regular cycles on my own at 38 and now at 47 I am having perfect 28 day cycles like clockwork, I am trying to conceive and I read about MYO increasing egg quality so I started taking it but I am worried that
the MYO inositol might lower my DHEA which is working for me at this age so I started low dose DHEA just 25 mg this cycle and I am not sure if I even ovulated because I am not having the typical progesterone symptoms (sore BBs etc.) that I normally get in the 2ww.
Their results: women who took
myo inositol had a better ovulation (65 % vs. 50 %) and pregnancy rate (30 % vs. 18 %) compared with the women who took metformin.
I started taking 4 grams of
myo inositol daily.
If you ask me simply putting the words
myo inositol and weight loss together to grab a headline is a bit misleading.
In any case, the change was quite small and it's worth pointing out that this was another trial where
myo inositol weight loss did not occur (Minozzi et al. 200827).
also
myo inositol has cut my cravings, now I find myself buying more fruit rather then the candy donuts cakes ect.
Besides the possibility of low blood sugar,
myo inositol is well tolerated.
Not exact matches
By helping your body use insulin effectively,
myo -
inositol helps to improve hormone balance and the process of ovulation.
Measurements of fetal levels of maternally infused stable isotope - labeled
myo -
inositol in normal pregnancies at term demonstrated that less than 10 % of fetal
inositol was maternally derived, suggesting little placental transport in late pregnancy (19)»
Effects of
myo -
inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Endocrine and clinical effects of
myo -
inositol administration in policystyc ovary syndrome.
Gerli, Papaleo, Ferrari, and DiRenzo (2007) found that
myo -
inositol helped women with PCOS who were not ovulating to begin ovulating again (in women with a BMI under 37).
Another study (Artini, DiBerardino, Papini, Genazzani, Simi, Ruggiero, & Cela, 2013) offered similar positive results on ovarian function, as well as improvement of insulin sensitivity in women with PCOS who were taking
myo -
inositol (in this study, the dosage was only 2g per day).
Randomized, double blind placebo - controlled trial: Effects of
myo -
inositol on ovarian function and metabolic factors in women with PCOS.
It is wise to find a healthcare practitioner you trust and discuss options like
myo -
inositol with him or her.
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase,
inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS,
myo -
inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting
It comes in two forms:
myo -
inositol and d - chiral
inositol, both of which have been shown to significantly reduce insulin levels and improve hormonal balance in PCOS (25, 26, 27).
A natural supplement called
myo -
inositol can be an effective treatment for Polycystic Ovary Syndrome (PCOS), which is one of the most common hormonal disorders in women.
A 2011 Italian double - blinded study confirmed that
myo -
inositol decreases testosterone and increases insulin sensitivity, making it useful for the treatment of PCOS.
BTW, I think
myo -
inositol helped me out in the regulation of hormones too...
I first reported my experience and blood results in June after 3 months of using
myo -
inositol (you can read my post here).
Metabolic and hormonal effects of
myo -
inositol in women with polycystic ovary syndrome: a double - blind trial.
When I first started taking
myo -
inositol, my baseline Ha1C was 5.2 %.
Assessment of the modification of the clinical, endocrinal and metabolical profile of patients with PCOS syndrome treated with
myo -
inositol].
As new research has shown that a combination of
myo and d - chiro
inositol improves PCOS better than
inositol alone, I have started using a product called Ovasitol, which is similar to Pregnitude but has d - chiro
inositol added.
Don't let the name of this product fool you: Pregnitude is a
myo - inositol (MYO) supplement for all women with PCOS, not just those looking to get pregna
myo -
inositol (
MYO) supplement for all women with PCOS, not just those looking to get pregna
MYO) supplement for all women with PCOS, not just those looking to get pregnant.
I've been taking
myo -
inositol supplement (4 grams daily) for 6 months now.
In this direct comparison that included patients both with and without insulin resistance,
myo -
inositol outperformed metformin when it came to reducing testosterone levels, hirsutism, and markers of inflammation (Jamilian et al. 201719).
This is likely due to the fact that D - chiro -
inositol seems to work by primarily improving the insulin sensitivity of our other organs, while
myo -
inositol is more targeted at the ovaries (Monastra et al. 20177).
This isn't the only time
myo -
inositol has proven to be better than metformin in certain circumstances.
These researchers also point out that based on the results of lab studies looking at how
myo -
inositol and D - chiro
inositol ratios are balanced in the ovary tissue of women with PCOS (Heimark et al. 201410), it's possible that using an overwhelming amount of
myo -
inositol over D - chiro -
inositol in a 40:1 ratio could «exert paradoxical effects».
Studies have shown that
myo -
inositol can improve insulin and glucose levels in women with PCOS.
When it comes to acne, only the study by Zacche and colleagues provides an indication of how effective
myo -
inositol can be in treating this symptom.
Ovasitol is a new
inositol product combining
myo - and d - chiro -
inositol in the body's naturally occurring ratio of 40 to 1.
As I have explained above, there is a high degree of confidence that
myo -
inositol significantly improves your chances of falling pregnant whether you're trying naturally, or you're getting a little help.
My thoughts are that if you're at a high risk of diabetes and not trying to conceive than D - chiro -
inositol could be a sensible way to go, while for everyone else I think that taking a combination of both
myo -
inositol and D - chiro -
inositol is probably going to give you the best results.
Endocrine and clinical effects of
myo -
inositol administration in polycystic ovary syndrome.
And since we're talking about one of the most commonly prescribed PCOS drugs, it's also worth mentioning that researchers are now investigating using
myo -
inositol to improve the efficacy of clomid for ovulation induction.
I will say that the majority of patients I work with have seen better menstrual cycles and ovulation with
myo -
inositol.
Randomized, double blind placebo - controlled trial: effects of
myo -
inositol on ovarian function and metabolic factors in women with PCOS.Europ rev med pharm sci.
What this tells us is that
myo -
inositol is fairly effective at reducing acne, but it still doesn't work for everyone with PCOS.
In a study of overweight women with PCOS that were given
myo -
inositol + folic acid during IVF, 32 % of women had a successful pregnancy within the 12 month study period, compared to just 12 % of women who only took a straight folic acid supplement without the
inositol (Artini et al. 201315).
The combined therapy with
myo -
inositol and D - chiro -
inositol reduces the risk of metabolic disease in PCOS overweight patients compared to
myo -
inositol supplementation alone.
27Minozzi, M.; D'Andrea, G.; Unfer, V. Treatment of hirsutism with
myo -
inositol: a prospective clinical study.
In a recent study of IUI patients with PCOS, pregnancy rates were improved by approximately 50 % (regardless of whether or not they had insulin resistance) after taking
myo -
inositol for just 3 months beforehand (Ozay et al. 201716).