He presented results from both SMA mouse models and patients that demonstrated SMN depletion results in muscle - intrinsic defects such as reduced satellite cell number, a delay in the myogenic program, reduced
myoblast fusion, and molecular homeostasis disruption.
Not exact matches
The
fusion of
myoblasts is a critical step in the formation of embryonic muscle fibers as it determines muscle size, among other things.
«We were able to identify the receptor BAI3, a protein at the surface of
myoblasts, as one of the crucial missing links in the
fusion of muscle cells,» adds Dr. Côté.