Sentences with word «myofiber»

Profile 2 — exploration of the role of myofiber contraction on skeletal muscle environment (PI: Dr. R Mounier).

Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise.

«They end up with many dysfunctional mitochondria, which compromise repair of injured myofibers.

Translational signaling responses preceding resistance training - mediated myofiber hypertrophy in young and old humans.

Effect of the different experimental conditions on the glycogen, intracellular glucose, and G6P content in cultures of human myofibers.

Although reactive oxygen species can damage cells when produced in high amounts, according to a study published online Sept. 5, 2017 by Science Signaling and featured on the journal's cover, these oxidative species are crucial signals that start the process of repairing myofiber.

Efficacy of 3 days / wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults

Loading up mitochondria with excess antioxidants inhibits this signaling process, blocking muscle repair, exacerbating myofiber damage and diminishing muscle strength.

For example, we discovered how the protein phosphatase calcineurin and its downstream effector protein NFAT act synergistically with the transcription factor MEF2 at transcriptional enhancer elements of selected genes, such as myoglobin, to medicate adaptive mechanisms by which skeletal myofibers acquire specialized contractile and metabolic properties in response to changing patterns of muscle contraction.

Treatment also restored a more normal size to anterior horn cells, and increased both total muscle area and myofiber diameter.

We previously demonstrated that numerous Wnt molecules are secreted in the local milieu during regeneration and showed that MuSC self - renewal is in part controlled by non-canonical Wnt7a / PCP signals sent by the regenerating myofibers.

Abstract During muscle regeneration, the conversion of muscle stem cells to terminally differentiated myofibers requires multiple cell fate transitions.

The cultures contain many multinucleated myofibers (× 200).

Note elongated median nuclei and the two parallel strands of striated myofibers.

Dystrophin helps muscle fibers maintain their integrity and resiliency during muscular contraction, and without it, myofibers undergo cycles of damage - induced degeneration and regeneration until the muscle's regenerative capacity is exhausted.

The self - renewing properties of satellite cells not only maintains the muscle stem cell population in the body, but also provides myogenic cells, which proliferate, differentiate, fuse, and lead to the formation of new myofibers whenever necessary to repair the damage.

Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell - mediated myonuclear addition: a cluster analysis.

Myokardia has two other drugs in the early stage of development; HCM - 2 which they hope will also lessen heart muscle contraction force («contractility») in hypertrophic cardiomyopathy and LUS - 1 to counteract the «scrambling» (= myofiber disarray) of heart muscle fibers that also occurs in HCM.

Myofiber size was appropriate in all muscles evaluated and no specific abnormalities were identified, making a congenital myopathy unlikely.

Properly functioning mitochondria are needed not only for energy production, but also to repair injured myofibers.

Effect of preculturing human satellite cell cultures in increasing concentrations of insulin on the basal and insulin - stimulated glucose transport activity in cultures of human myofibers.

In the present seminar, I will summarize our findings concerning the role of Srf in myofibers to control muscle mass and I will present recent data identifying Srf as a master regulator of muscle stem cell fusion and demonstrating the implication of F - actin architecture in this process.

The incorrect positioning of nuclei in the center of myofibers is a hallmark of a class of muscular diseases called centronuclear myopathies (CNM), which includes myotubular myopathy.

Studies had shown that myofibers, the cells making up these muscles, were larger and greater in number — producing a more powerful bite.

The force that myofibers generate is transmitted across the muscle, causing stress that can injure the myofibers.

This permits chronic and excessive oxidation of the myofibers and disruption of the proper oxidant - antioxidant balance.»

To make voluntary movements like climbing stairs, lifting a gym bag or swiping open a smartphone app, myofibers must produce force.

Mitochondria help injured muscle cells (myofibers) repair by soaking up calcium that enters from the site of injury and using it to trigger increased production of reactive oxygen species.

We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).

Abstract Regeneration of the adult skeletal muscle tissue relies on a pool of quiescent muscle stem cells located in a niche around the myofibers: the satellite cells (MuSCs).

Myofibers in Dysfprmd homozygotes undergo degeneration and regeneration, and their nuclei are placed centrally.