Sentences with phrase «myofibroblast formation»
Previous research had shown that AHR activation decreases transforming growth factor beta (TGFβ), a cytokine that induces myofibroblast formation.
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Myofibroblasts produce large amounts of extracellular matrix material such as collagen, are contractile, and secrete a variety of cytokines and chemokines, all of which enhance scar formation.
The ligands also interfered with other aspects of TED tissue remodeling including collagen production, filament formation, and myofibroblast contraction.