Preliminary data we have now obtained further indicate that in somite cells, the activation of the NOTCH pathway triggers a «signalling module» that couples the initiation of
myogenesis with the epithelial - mesenchymal transition (EMT) that allows them to migrate into the growing muscle.
Not exact matches
Accordingly, our data suggests that the failure of regenerative
myogenesis to keep pace
with disease progression in DMD is not due to muscle stem cell exhaustion, but rather is due to a cell - autonomous deficiency in asymmetric division.
However, Setd7 expression increased
with the progression of
myogenesis in vitro indicating the potential importance of this event for skeletal muscle development and regeneration in vivo.
Title: Muscle satellite cells are primed for
myogenesis, but maintain quiescence
with sequestration of Myf5 mRNA targeted by microRNA - 31 in mRNP granules Authors: Crist CG, Montarras D, Buckingham M Date: 2012 Publication Details: Cell Stem Cell 2012 Jul 6:11 (1): 118 - 126