However, researchers from the laboratory of Nenad Bursac (Duke University, Durham, NC, USA) have recently described the production and differentiation of induced
myogenic progenitor cells (iMPCs) from hPSCs into the first entirely hPSC - derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation [5].
In this study, Chazaud et al., evidenced that endothelial cells (ECs) and
myogenic progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration.
«Starting with pluripotent stem cells that are not muscle cells, but can become all existing cells in our body, allows us to grow an unlimited number of
myogenic progenitor cells,» said Nenad Bursac, professor of biomedical engineering at Duke University.
Abstract We discovered that a subset of satellite cells in skeletal muscle are self - renewing stem cells that give rise to
myogenic progenitors through asymmetric apical - basal cell divisions.
Darabi R, Arpke RW, Irion S, et al., Human ES - and iPS - derived
myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice.