Review of «Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of
Myogenic Stem Cells with Improved Therapeutic Potential» from Cell Stem Cell by Stuart P. Atkinson
Judson RN, Quarta M, Oudhoff MJ, et al., Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of
Myogenic Stem Cells with Improved Therapeutic Potential.
Characterized other proteins and pathways that modulate proliferation and differentiation of
myogenic stem cells, hypertrophic growth of the heart, mitochondrial biogenesis and fiber type — specific gene expression in skeletal muscles.
Not exact matches
«Starting with pluripotent
stem cells that are not muscle cells, but can become all existing cells in our body, allows us to grow an unlimited number of
myogenic progenitor cells,» said Nenad Bursac, professor of biomedical engineering at Duke University.
Abstract We discovered that a subset of satellite cells in skeletal muscle are self - renewing
stem cells that give rise to
myogenic progenitors through asymmetric apical - basal cell divisions.
Using mouse skeletal muscle
stem cells as a model, we show that accumulating transcripts specifying the
myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.