Sentences with phrase «myopathy causes»

Native American myopathy causes muscle weakness from birth and other severe problems that can lead to death before adulthood.

Myopathy caused by a histiocytic sarcoma in a cat.

Not exact matches

This dose would now be considered a low dose, but the authors note that randomised trials of higher doses have not found that statins cause an increase in muscle related symptoms, other than the very small increase in myopathy.

Often, those smaller animals express the genetic abnormality very differently from humans, says clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who studies the myopathies and their genetic causes in both children and zebrafish.

In addition to the Great Danes, researchers, including Laporte, have found Labrador retrievers that bear two other gene mutations that cause different forms of recessive centronuclear myopathy, one linked to chromosome 2 and the other to the X chromosome.

The researchers showed that a progressive mitochondrial myopathy, PEO - disease, and infantile spinocerebellar ataxia, both caused by mitochondrial dysfunction, lead to shaken folate - metabolism, irrespective of nutrient intake.

Peripheral nervous system complications of sepsis include two conditions, critical illness polyneuropathy and critical illness myopathy, which cause muscle weakness and inability to wean from a ventilator.

More broadly, he said, «These findings are part of an emerging theme that there is a whole spectrum of diseases that includes ALS, and some forms of dementia and myopathy, that are caused by disturbance in the behavior of these structures that perturbs cellular organization.»

Myopathies are frequent diseases and can be caused by inherited genetic defects (e.g., muscular dystrophies), or by endocrine inflammatory (e.g., polymyositis), and metabolic disorder.

In his graduate research, Linsley discovered the gene Stac3 is a component of the excitation - contraction machinery in skeletal muscle and the mechanism by which mutations in that gene cause Native American Myopathy, a rare but devastating congenital disease.

For example, the m. 3243A > G mutation can cause mitochondrial myopathy encephalopathy, lactic acidosis, and stroke (MELAS) when present at a frequency greater than 59 % [21].

Muscle inactivation of mTOR causes metabolic defects and dystrophin downregulation leading to a severe myopathy

The screening proposed here is expected to lead to novel strategies for the treatment of centronuclear myopathies by reducing muscle weakness caused by central nuclei in diseased muscles.

Defects in these genes are associated with several forms of myopathies (41), including limb - girdle muscular dystrophy 2F, which causes limb musculature wasting and locomotory troubles in juvenile individuals.

Sialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla disease.

University of Michigan researchers have discovered a new cause of congenital myopathy: a mutation in a previously uncharacterized gene, according...

In addition, HER2 is expressed in many normal tissues, giving systemic HER2 - targeted antibody therapy the potential to cause toxicity in a subset of patients, including cardiac myopathy, congestive heart failure, and pulmonary toxicity [14], [15].

It is known that long - term treatment of rats with the drug causes myopathy and decreased skeletal muscle protein concentration (20,21).

Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs.

Other then trauma or injury, some other myopathies may also cause a sprain to occur.

Muscle - type phosphofructokinase (PFK) deficiency causes alkaline - induced hemolytic crises and exertional myopathy in English Springer Spaniel (ESSP) dogs and is inherited as an autosomal - recessive trait.

Muscle inflammation due to many autoimmune diseases (Masticatory myositis, Eosinophilic Myositis, Polymyositis, Myositis Ossificans, Fibrotic myopathy, etc.) can be the cause of high CK blood levels — particularly early in the disease or during flareups.

Certain rare, inherited, genetically based, diseases that cause muscle destruction can also be the cause of high CK levels (primary metabolic myopathies, myotonia congenita, etc.).