Sentences with word «myosin»

Hickson, et al., Glutamine prevents down regulation of myosin heavy chain synthesis and muscle atrophy from glucocorticoids, Am J Physiol, 1995, 268: E730 - E734.

A phylogenetic analysis of myosin heavy chain type II sequences corroborates that Acoela and Nemertodermatida are basal bilaterians.

The interaction occurs principally in the biosynthetic and secretory pathways (Sans et al 2001) and SAP97 provides a linkage between the AMPA receptor subunit and the microtubule - based transport mechanisms, via an interaction with the motor protein myosin VI (Wu et al 2002).

Titin ensures that the actin and myosin filaments of a sarcomere are positioned correctly and re-adjusts the sarcomere to its original length after muscle activity,» explains structural biologist Kristina Djinović - Carugo.

How binding of a small molecule can increase the performance of a muscle by promoting an increase in myosin motor force was unclear.

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

The finding of mutations in an important cardiac protein called myosin binding protein C in affected lines of Maine Coon and Ragdoll cats supports a heritable, genetic component of HCM in these breeds.

Stress fi bers of Hela cell: Antibody staining with Alexa Fluor 488 (green) for actin, Alexa Fluor 568 (red) for myosin heavy chain.

Many of the downregulated genes are smooth muscle cytoskeletal elements, including TCAP (titin - cap), TPN1 (tropomyosin), DMD (dystrophin), SMTN (smoothelin), TAGLN (transgelin), MYH11 (smooth muscle myosin heavy chain 11), and CNN1 (smooth muscle calponin 1).

This process combines information derived from myosin ATPase histochemistry with histochemistry of certain enzymes that are involved in energy metabolism.

To accomplish this, we used homologous recombination to ablate nonmuscle myosin heavy chain (NMHC) II - B by inserting cDNA encoding green fluorescent protein (GFP)- NMHC II - A into the first coding exon of the Myh10 gene, thereby placing GFP - NMHC II - A under control of the endogenous II - B promoter.

The French team and a British group that discovered the mouse gene both decided to see if the mutation — which hampers the production of a protein called myosin VIIA — might, as in the mice, explain inherited deafness without other sensory loss.

Sattarzadeh, A., Schmelzer, E., and Hanson, M. R. (2011) Analysis of organelle targeting by DIL domains of the Arabidopsis myosin XI family, Frontiers in plant science 2, 72.

For example, myosin mutations are believed to be behind an inherited disease that causes the walls of the heart muscle to become too thick or too thin.

Heart: Scientists of my generation didn't speak much about the heart unless, like me, they were working on myosin structure or some such architectural piece.

Understanding how tiny molecular motors called myosins use energy to fuel biological tasks like contracting muscles could lead to therapies for muscle diseases and cancers, say a team of researchers led by Penn State College of Medicine scientists.

Mutations in the gene responsible for producing a particular protein in heart muscle cells - MYBPC3 (the cardiac myosin binding protein C gene) have been identified commonly in both Maine Coon and Ragdoll cats affected with HCM (a different mutation is present in the two breeds), and similar mutations may also be seen in some other breeds.

Seeing myosin tails getting stretched in relaxed muscle is «a complete novelty,» he says.

Capitanio M., Canepari M., Maffei M., Beneventi D., Monico C., Vanzi F., Bottinelli R., and F. S. Pavone, Ultrafast force - clamp spectroscopy of single molecules reveals load dependence of myosin working stroke, Nature Methods 9, 1013 - 1019 (2012).

His recently published work defined the role of Rab11a and Rab8a interactions with myosin Vb in the development of severe neonatal diarrhea in children with Microvillus Inclusion Disease and he has recently published work on the phenotypes of mouse models of MYO5B KO.

One of the goals of this work is to measure the force generated by a single myosin molecule pulling against an actin filament.

Tra2ß Protein Is Required for Tissue - specific Splicing of a Smooth Muscle Myosin Phosphatase Targeting Subunit Alternative Exon.

Their recent study, published in PNAS (3), characterizes the mechanism of action of a smooth muscle myosin inhibitor, CK - 2018571, that induces smooth muscle relaxation and can be used to treat diseases involving smooth muscle hypercontractility, such as asthma and chronic obstructive pulmonary disease.

It is driven by the motion of the motor protein myosin along filamentary actin strands.

Complementary collaborative work between Cytokinetics and the team headed by Anne Houdusse has also uncovered how highly specific small molecules can stop smooth muscle myosin activity.

In muscles, myosins generate movement by interacting with actin filaments, a fibrous track they can bind to and move along.

Spudich and Sheetz had, for the first time, created an in vitro assay for myosin movement.

These insights provide details about how myosin motor proteins work, and this knowledge could advance the understanding of diseases related to movement on a molecular level.

Muscle diseases are the major area of interest for myosin researchers.

«We thought we knew everything about myosin — how it works, how it makes muscles contract,» he says.

This process involves using immunohistochemistry to differentiate between individual muscle fibers in the basis of the different myosin heavy chain isoforms.

Riccardo Cicchi received his Master Degree in physics in 2003 at the University of Florence, working on skeletal muscle myosin mechanics, using a multiple optical tweezers setup.

He wrote papers like «Cloning and characterization of mouse brush border myosin - I in adult and embryonic intestine.»

Disconnected from the mother through a clean mechanism of molecular competition between anti-hormones and hormones, and catapulted toward the network of sewage system through the action of specific stimulators of the uterine myosins, the embryo ends its existence in an unspectacular fashion.

During such a long race, significant muscle breakdown can occur, dumping myosin into the bloodstream to be filtered out by the kidneys.

Petit speculates that those who are just deaf may somehow scrape together enough myosin VIIA — thought to help form the sound - detecting hairs in the inner ear — and devote it instead to the eye's rods and cones that detect light, where its role is critical, but unknown.

This suggests, say the researchers, that myosin stores elastic energy that can be used in the next contraction in the same way a stretched spring holds onto energy and releases it when it recoils.

High - resolution microscope image of an invasive breast cancer cell (magenta) expressing Myosin - 10 induced «sticky - fingers» (green).

Take myosin, the major protein in heart muscle and «the most studied protein in muscle biology for decades,» according to Eric Olson, a University of Texas molecular biologist who studies the role of microRNA in heart tissue and heart failure.

So all this time, we thought myosin was there to make muscles contract.

The end of Olympics, yet others will groan, facing the prospect of ounce - brained athletes entirely muscled by fast - twitching myosins.