Complementary collaborative work between Cytokinetics and the team headed by Anne Houdusse has also uncovered how highly specific small molecules can stop smooth muscle
myosin activity.
The work by the Houdusse team and Cytokinetics highlights how specific modulators of
myosin activity have great potential to provide new treatments against human diseases.
Not exact matches
Titin ensures that the actin and
myosin filaments of a sarcomere are positioned correctly and re-adjusts the sarcomere to its original length after muscle
activity,» explains structural biologist Kristina Djinović - Carugo.
To determine whether FLRG can also inhibit myostatin
activity in vivo, I generated a construct in which the FLRG coding sequence was placed downstream of a
myosin light chain promoter / enhancer.
Myosin II
activity dependent and independent vinculin recruitment to the sites of E-cadherin mediated cell - cell adhesion.
Myosin IIA's
activity is regulated by RhoA and Rho - associated protein kinase (ROCK) signaling.