Sentences with phrase «myosin molecule»
One of the goals of this work is to measure the force generated by a single myosin molecule pulling against an actin filament.
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Recently, the combination of these two techniques has produced a new generation of experimental setups enabling the simultaneous manipulation of a biological substrate (for example an actin filament or a DNA molecule) and detection / localization of an interacting partner enzyme (for example myosin or a DNA - binding protein).
Capitanio M., Canepari M., Maffei M., Beneventi D., Monico C., Vanzi F., Bottinelli R., and F. S. Pavone, Ultrafast force - clamp spectroscopy of single molecules reveals load dependence of myosin working stroke, Nature Methods 9, 1013 - 1019 (2012).
How binding of a small molecule can increase the performance of a muscle by promoting an increase in myosin motor force was unclear.
Complementary collaborative work between Cytokinetics and the team headed by Anne Houdusse has also uncovered how highly specific small molecules can stop smooth muscle myosin activity.
This causes the two main protein molecules (Aktin und Myosin) inside the muscle fibres to move relative to each other resulting in shortening (contracting) and lengthening (relaxing) muscle movement.