Capitanio M., Canepari M., Maffei M., Beneventi D., Monico C., Vanzi F., Bottinelli R., and F. S. Pavone, Ultrafast force - clamp spectroscopy of single molecules reveals load dependence of
myosin working stroke, Nature Methods 9, 1013 - 1019 (2012).
Not exact matches
Heart: Scientists of my generation didn't speak much about the heart unless, like me, they were
working on
myosin structure or some such architectural piece.
«We thought we knew everything about
myosin — how it
works, how it makes muscles contract,» he says.
One of the goals of this
work is to measure the force generated by a single
myosin molecule pulling against an actin filament.
His recently published
work defined the role of Rab11a and Rab8a interactions with
myosin Vb in the development of severe neonatal diarrhea in children with Microvillus Inclusion Disease and he has recently published
work on the phenotypes of mouse models of MYO5B KO.
The
work by the Houdusse team and Cytokinetics highlights how specific modulators of
myosin activity have great potential to provide new treatments against human diseases.
Complementary collaborative
work between Cytokinetics and the team headed by Anne Houdusse has also uncovered how highly specific small molecules can stop smooth muscle
myosin activity.
These insights provide details about how
myosin motor proteins
work, and this knowledge could advance the understanding of diseases related to movement on a molecular level.
A drug that prevents
myosin from
working in cancer cells could keep them from invading other cells or metastasize into different organs.
When you are able to increase the number of contractile proteins called actin and
myosin, it increases the ability of muscles to contract and perform physical
work.