Sentences with phrase «myostatin activity»

In addition to the propeptide, other binding proteins are capable of regulating myostatin activity in vitro, including follistatin [19], [21], FLRG [22], and Gasp - 1 [23].

In order to determine whether this effect of follistatin results solely from inhibition of myostatin activity, I analyzed the effect of this transgene in myostatin - null mice.

As a result, there has been considerable effort directed at developing strategies to modulate myostatin activity in clinical settings where enhancing muscle growth may be beneficial.

Hence, there is considerable interest in developing agents capable of inhibiting myostatin activity for both agricultural and human therapeutic applications.

Moreover, loss of myostatin activity resulting either from postnatal inactivation of the Mstn gene [3], [4] or following administration of various myostatin inhibitors to wild type adult mice [5]--[7] can also lead to significant muscle growth.

To determine whether FLRG can also inhibit myostatin activity in vivo, I generated a construct in which the FLRG coding sequence was placed downstream of a myosin light chain promoter / enhancer.

To determine whether the FLRG transgene was causing increased muscle growth by blocking myostatin activity, I examined the effect of combining the FLRG transgene with a loss - of - function mutation in the myostatin gene.

One of these is the follistatin related protein, FLRG, which has been demonstrated to be capable of inhibiting myostatin activity in vitro.

Not exact matches

Mstn − / − mice carrying a follistatin transgene had about four times the muscle mass of wild type mice, demonstrating the existence of other regulators of muscle mass with similar activity to myostatin.

I have presented data showing that FLRG, like follistatin, can promote muscle growth when expressed as a transgene in skeletal muscle and that both of these molecules appear to act by blocking not only myostatin but also other ligands with similar activity to myostatin.

Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin / activin - blocked mdx mice.

It is the flip - side of myostatin, as increased follistatin blocks the activity of myostatin: either increased follistatin or reduced myostatin produce similar outcomes in animal studies, with treated individuals demonstrating increased muscle mass.

To test Cas9 / gRNA activity in goat primary fibroblasts, we designed six gRNAs targeting myostatin (MSTN), nucleoporin 155 (NUP), prion protein (PrP), and beta - lactoglobulin (BLG), respectively (Figure 1A).

Bodybuilders who use myostatin blockers experience a dramatic increase in muscle mass in response to weight training and reduced levels of body fat, mainly because of an increased fat breakdown and an increased activity of the brown body fat, according to a study from Singapore.