Sentences with phrase «myostatin resulted»

Published this week in the journal Proceedings of the National Academy of Sciences, the scientists found that inhibiting activin A, activin B and myostatin resulted in skeletal muscle mass increase by as much as 150 per cent in preclinical models.

Not exact matches

There are interesting similarities between the results of the current study and published data from leptin - deficient mice with genetic ablation of the atrophic hormone myostatin (55, 56).

Conceivably, this maternal effect could result from transfer of myostatin or a downstream mediator either prenatally from the maternal to fetal circulations or postnatally from the mother to the offspring during nursing; in this respect, myostatin mRNA has been reported to be expressed in the mammary gland of lactating pigs [24].

Taken together, these results suggest that the maternal effect on muscle mass results most likely from prenatal transfer of some mediator from mother to fetus, perhaps myostatin itself.

This finding taken together with the results of cross fostering experiments suggest that muscle mass can be influenced by prenatal transfer of some mediator from mother to fetus; although myostatin itself is the most obvious candidate for this mediator, additional experiments will be required to prove this definitively.

Moreover, loss of myostatin activity resulting either from postnatal inactivation of the Mstn gene [3], [4] or following administration of various myostatin inhibitors to wild type adult mice [5]--[7] can also lead to significant muscle growth.

As a result, there has been considerable effort directed at developing strategies to modulate myostatin activity in clinical settings where enhancing muscle growth may be beneficial.

In order to determine whether this effect of follistatin results solely from inhibition of myostatin activity, I analyzed the effect of this transgene in myostatin - null mice.

As a result of a number of natural animal lineages with this mutation, myostatin knockout is by far the most examined and tested of all potential gene therapies.

Secondly, the study lasted just 2 weeks, and yes favorable results were obtained, via an average change of +49.2 % (follistatin) to -16.6 % (myostatin), however the study duration was far from sufficient to observe muscle growth differences.

It is also important to note that these results were observed in middle aged people, who possess higher levels of myostatin and lower follistatin to begin with.

It regulates myostatin - signaling pathways, leading to lower action of myostatin inhibition that results in more muscle fiber building.

«Supplementation with creatine resulted in greater increases in muscle mass and strength, and these improvements were accompanied by more decreased myostatin levels.»

There are interesting similarities between the results of the current study and published data from leptin - deficient mice with genetic ablation of the atrophic hormone myostatin (55, 56).