Sentences with word «nanocarriers»

During the past year the team was awarded an National Science Foundation and two NIH grants to design nanocarriers for targeted drug delivery through a combination of computer modeling and laboratory experiments.

Because they can be programmed to travel the body and selectively target cancer and other sites of disease, nanometer - scale vehicles called nanocarriers can deliver higher concentrations of drugs to bombard specific areas of the body while minimizing systemic side effects.

Employing reactive polypept (o) ides to build a variety of different nanocarriers with different functions possible...

Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood... more»

Currently, the most common sustained nanocarrier delivery systems hold nanomaterials within polymer matrices.

However, recent work by a group of researchers led by Thomas H. Epps, III, and Millicent Sullivan in the Department of Chemical and Biomolecular Engineering at the University of Delaware has shown that routine procedures in handling and processing nanocarrier solutions can have a significant influence on the size and shape of these miniscule structures.

«With further research we hope to create a nontoxic nanocarrier that could provide targeted delivery of the TM - 025 and TM - 026 analogs specifically to cancer cells,» said Gitali Indra, an OSU assistant professor and also a lead and corresponding author on the study.

The introduction of nanocarriers as delivery vehicles for common chemotherapy agents such as the drug irinotecan, has led to improved survival of patients with this disease.

«This is the first nanocarrier - drug combination that shows therapeutic effects for three to four months with a single dose.

The team used a nanogel, a specialized nanocarrier, for drug delivery made up of two molecules — dextran (a sugar) and lysozyme (a protein)-- which mesh into a spaghetti - like ball that can fill with water to expand and contract.

Pierpapolo Ceci, PhD, scientist at MoLiRom, expert in protein based nanocarriers for theranostic.

Research Paper Cascade - amplifying synergistic effects of chemo - photodynamic therapy using ROS - responsive polymeric nanocarriers Chun - Yang Sun, Ziyang Cao, Xue - Jun Zhang, Rong Sun, Chun - Shui Yu, Xianzhu Yang Theranostics 2018; 8 (11): 2939 - 2953.

Lipidots ™ is its lead technology, versatile nanocarriers for application in molecular imaging and the delivery of nanopharmaceuticals.

In the field of nanomedicine, CEA - Léti has developed, over the past 9 years, a growing expertise in molecular optical imaging based on fluorescence imaging, and on nanocarriers for drug delivery.

A Fred Hutch and University of Washington team of virologists and bioengineers led by Dr. Keith Jerome has received a $ 200,000 grant — the first phase of up to $ 1.5 million in milestone - driven funding over four years — to develop nanocarrier technology to deliver therapies to reservoirs of dormant, HIV - infected cells.

Because they can be programmed to travel the body and selectively target cancer and other sites of disease, nanometer - scale vehicles called nanocarriers can deliver higher concentrations of drugs to bombard specific areas...

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small - molecule therapeutics to specific locations in the body.

A common assumption is that once a nanocarrier is created, it maintains its size and shape on the shelf as well as in the body.

So simple agitation can completely alter the distribution profile of the nanocarrier - drug complex in the body.»

«At 75 nanometers, a nanocarrier may deliver its cargo directly to a tumor,» Epps says.

«We designed a nanocarrier to deliver two passengers: (1) miR - 34a, which degrades hundreds of oncogenes; and (2) a PLK1 small interfering RNA (siRNA), that silences a single gene,» Prof. Satchi - Fainaro says.

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

«This molecule on the surface of the nanocarrier has specialized preference for the lung to enhance localized and targeted drug delivery,» says Eckmann.

The gel itself re-assembles into the nanocarriers, so after all of the drug has been delivered, no residual material is left to induce inflammation or fibrous tissue formation.

To bypass this issue, Scott developed a nanocarrier using self - assembled, filament - shaped nanomaterials, which are loaded with a drug or imaging agent.

Nanocarriers can also deliver drugs and diagnostic agents that are typically not soluble in water or blood as well as significantly decrease the effective dosage.

Scott's team designed a nanocarrier formulation that — after quickly forming into a gel inside the body at the site of injection — can continuously release nanoscale drug - loaded vehicles for months.

Although this method might seem ideal for treating diseases, nanocarriers are not without their challenges.

Berkeley Lab researchers have developed a new family of nanocarriers, called «3HM,» that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.

«These nanocarriers developed by our team have a variety of applications in medication and as a gene transfection agent for biological research,» said Dr Yi - Yan Yang, who led the project team comprising Yong Wang, Shujun Gao, Wen - Hui Ye and Ho Sup Yoon.

The nanocarriers will be modified with antibodies that target triple - negative and HER2 - positive breast cancers, and will be able to release the drugs directly into the tumor.