Lino Ferreira was able to overcome these difficulties and establish himself in his native Portugal thanks to a $ 1.7 million grant he received 5 years ago to develop
nanomedicines using stem cells.
Like Doxil, all other existing cancer
nanomedicines use specially engineered nanoparticles to transport an existing chemotherapy agent.
Not exact matches
With this in mind, scientists from the Center for
Nanomedicine at Johns Hopkins, led by Hanes, encapsulated the BPTES in a nanoparticle capsule coated in polyethylene glycol, a molecule
used widely in medicines and industrial products,
using a method they developed to provide a more uniform coating.
In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a
nanomedicine that combines photodynamic therapy — the
use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.
Professor Knight added: «Super resolution microscopy is a major step forward and we are looking forward to
using this technology in a wide range of applications from stem cell behaviour to understanding arthritis or the development of
nanomedicine.»
Co-lead scientist Associate Professor Tina Wong, who is the head of the Ocular Therapeutics and Drug Delivery Research Group at the Singapore Eye Research Institute, said the new
nanomedicine will benefit the elderly, as they often forget to
use the daily eye drops, leading to the worsening of their conditions.
Asst Prof Xu, who is also a researcher at the NTU - Northwestern Institute for
Nanomedicine, said their new method may solve some of the most pressing problems faced in chemotherapy
used to treat cancer.
The point was further emphasized in a press release put out by Nature Nanotechnology this week: «These findings suggest that direct and indirect effects of nanoparticles on cells are equally crucial when considering the potential risks of their
use in
nanomedicine.»
«Age - old malaria treatment found to improve nanoparticle delivery to tumors:
Nanomedicine researchers find new
use for 70 - year - old drug.»
It is also the first example of
using targeted
nanomedicine to reduce atherosclerosis in animals.
More than just an extension of «molecular medicine,»
nanomedicine will employ molecular machine systems to address medical problems, and will
use molecular knowledge to maintain and improve human health at the molecular scale.