Increasing the stiffness of cancer cell membrane enhanced the entry of polymer
nanoparticles through pathways rich in cholesterol.
«Previously, we've delivered
nanoparticles through the bloodstream and shown that they inhibit inflammation in a model of rheumatoid arthritis.
A magnet pulled «smart»
nanoparticles through a mouse's bloodstream into its brain, similar to this figure.
Khizroev used the tail - to - head trick to spread
the nanoparticles through the brain and mimic IV drug delivery in humans.
a) Gold nanoparticle catalyst (Au / HAP - NC), b) Images of gold nanoparticles (black dot in red circle) through Transmission Electron Microscope, c) Annular Dark Field of gold
nanoparticles through Scanning Electron Microscope.
Not exact matches
To get around this gatekeeper, researchers have tried a number of approaches — including attaching drugs to
nanoparticles that might slip
through the BBB.
, is funded
through a National Science Foundation CAREER award and bridges previous research focused on designing
nanoparticles for catalytic applications.
By including chemotherapy molecules in the
nanoparticle structures when they are assembled, the molecules could be drawn into tumors — and then released with the application of a light at a shorter wavelength that triggers disassembly
through photo - cleavage.
Beyond the activity of the drugs, the plasmonic effects of the gold
nanoparticles could heat the
nanoparticles when they are subjected to light, attacking the cancer cells
through a second route.
These materials are sensitive to light, and cause the
nanoparticles to self - assemble
through a photo - dimerization process — crosslinking — when subjected to light at a wavelength of 365 nanometers.
When two spherical
nanoparticles collide, energy dissipates around the initial point of contact on each one instead of propagating all the way
through both.
It also enables the
nanoparticle size to be tightly controlled, which is important when trying to block some wavelengths of light while allowing others to pass
through.
Nanoparticles likely enter the environment
through wastewater, where they accumulate in biosolids (sewage sludge) at wastewater treatment plants.
They'll also work with materials scientists to create a reproduction that mirrors the composition of different - shaped
nanoparticles to see how they navigate
through the bloodstream so the team can run virtual tests of new treatments in nanomedicine.
«We need to design
nanoparticles that will, like a lock - and - key mechanism, travel
through the body and interact only with the diseased cell surface,» says Marth.
The
nanoparticle, according to the scientists, helps the drug slip
through capillaries near cancer cells and remain within the tumor longer than it would otherwise.
«With this force in hand both the charge on the
nanoparticle and the microcavity charge density could be calculated
through a series of experiments.»
«Using our new technique, we could not only see that individual
nanoparticles showed different extents of reaction at a given time, but also how the reaction worked its way
through the interior of each
nanoparticle,» Cabana said.
They injected the
nanoparticles into a mouse's bloodstream
through its tail.
Once the
nanoparticles squeezed
through the barrier and the mouse was exposed to a weak magnetic field, the critter's brain responded by firing electrical signals.
In testing with hydrogen peroxide, a strong oxidizing agent, the researchers found their most effective cerium oxide III
nanoparticles performed nine times better than a common antioxidant, Trolox, at first exposure, and held up well
through 20 redox cycles.
«
Through nanocharges it is possible to add other properties to the intrinsic properties of the basic materials:
nanoparticles, nanoclays, fibres, etc..
HST researchers have experimented with polymer - coated iron oxide
nanoparticles held together by DNA tethers to help them create a visual image of a tumor
through magnetic resonance imaging.
«We addressed this challenge
through the controlled, multiscale assembly of
nanoparticles by leveraging the kinetics of polymer crystallization.»
«We have been developing the expertise required to grow intricate core / shell and other well defined
nanoparticles for many years,» Vela said, «
Through our collaboration with Emily Smith's group, we hope to continue making inroads in our ability to manipulate and direct energy flows at the nanoscale.»
Reactants can flow into the hollow structure
through holes in the faces, interacting with more platinum atoms in the chemical reaction than would be the case on a flat sheet of platinum or traditional, nonhollowed
nanoparticles.
However, if a voltage is applied from one side of the film to the other, electrons can pass from one layer of gold to the next by burrowing
through the cadmium sulfide
nanoparticles in between.
A new technique invented at MIT can measure the relative positions of tiny particles as they flow
through a fluidic channel, potentially offering an easy way to monitor the assembly of
nanoparticles, or to study how mass is distributed within a cell.
They also reproduced the «cleaning» effect of
nanoparticles, which go
through in lymph nodes, by «washing» lymph off them and reinjecting them into the blood serum.
He then placed small amounts of the charcoal - colored
nanoparticles into a reaction chamber and passed mixtures of carbon dioxide and hydrogen
through the powdery material.
It can also keep
nanoparticles from clumping together, so they spread widely
through a liquid.
In this research, which has yet to be published, the
nanoparticles would be injected instead of applied topically, so that they could circulate
through the bloodstream and slowly release their nitric oxide payload.
Hoffmann began working with
nanoparticle semiconductors
through his academic and professional career.
«Potentially harmful
nanoparticles produced
through burning coal: Environmental scientists led by the Virginia Tech College of Science have discovered that the burning of coal produces incredibly small airborne particles of a highly unusual form of titanium oxide with the potential to be toxic to humans.»
Meanwhile, Glotzer's group has championed the role of
nanoparticle shape in guiding the assembly of crystal structures
through computer simulation.
In 1996, he introduced the concept of using
nanoparticles as atoms and synthetic DNA — the blueprint of life — as a chemically programmable bond to make designer materials based upon the ability of the particles to recognize one another
through sequences immobilized on their surfaces.
Mirkin's group has pioneered many structures
through the use of DNA strands as a sort of smart glue, linking
nanoparticles together in a particular way.
But the authors say further attention should be given to
nanoparticles to which humans are directly exposed,
through the air or the skin.
The group that got F3 with the Photofrin - carrying
nanoparticles came
through the best: they lived for, on average, 33 days; three of the five in this grouping lived for 60 days, and two of those three appeared tumor - free after six months.
But the independent report, issued by the Royal Society and the Royal Academy of Engineering on Thursday, recommends that «free»
nanoparticles, or those that could come into direct contact with humans
through the air or the skin, be subject to fresh regulatory controls.
The drug is a spray of
nanoparticles, which are small enough to be absorbed
through the lungs» air sacs and into the bloodstream.
The
nanoparticles collide to produce scatterings of light, like sun streaming
through clouds, doing away with the need for bulky mirrors.
Melander's team, which is not involved in any of DeSimone's work, is currently testing their gold
nanoparticles» ability to cross
through a simulation of the blood — brain barrier that prevents many substances from passing into the brain from the bloodstream.
The device sends a tiny amount of silver
nanoparticle tracers in rapid pulses
through a solid column, simulating the much longer path the particles would travel in a well.
When ingested,
nanoparticles pass into the blood and lymph system, circulate
through the body and reach potentially sensitive sites such as the spleen, brain, liver and heart.
Barenholz's
nanoparticles generally stayed in the bloodstream and avoided the heart and other organs, but when they reached the leaky blood vessels in the tumor, they slipped
through those holes.
Any large molecules floating outside the cell — such as RNA, proteins or
nanoparticles — can slide
through the membrane during this disruption.
To show that the enzymes were trapped inside the FMS pores, the team stained the protein - FMS complex with gold
nanoparticles and documented the enzyme - in - pore complex
through electron microscopy.
Light can be used to activate normal, non-genetically modified neurons
through the use of targeted gold
nanoparticles, report scientists from the University of Chicago and the University of Illinois at Chicago.
A nanometre is 1 billionth of a metre, hence
nanoparticles are small enough to move
through the bloodstream.