Sakuma S, Higashino H, Oshitani H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari KI, Tachikawa H, Kimura R, Nakamura K, Kumagai H, Gore JC, Pham w. Essence of affinity and specificity of peanut agglutinin - immobilized fluorescent
nanospheres with surface poly (N - vinylacetamide) chains for colorectal cancer.
Led by Prof. Matthias Kling, the LAP - physicists studied silica
nanospheres with diameters of 50 to 550 nanometers, which were chemically synthesized by Eckart Rühl's group at Freie Universität Berlin.
But it's not so easy to make
nanospheres with precisely placed linker strands.
Not exact matches
When the scientists mixed nanocubes coated
with DNA tethers on all six sides
with nanospheres of approximately the same size, which had been coated
with complementary tethers, these two differently shaped particles did not segregate as would have been expected based on their normal packing behavior.
The emission of electrons is like a ping - pong game on the surface of the
nanospheres that can be controlled
with a precision of attoseconds,» explains Prof. Thomas Fennel from the University of Rostock.
The researchers also found that nanorods targeted to lung tissue in mice accumulated at a rate that was two-fold over
nanospheres engineered
with the same targeting antibody.
Sakuma S, Kumagai H, Shimosato M, Kitamura T, Mohri K, Ikejima T, Hiwatari KI, Koike S, Tobita E, McClure R, Gore JC and Pham W. Toxicity studies of coumarin 6 - encapsulated polystyrene
nanosphere conjugated
with peanut agglutinin and poly (N - vinylacetamide) as a colonoscopic imaging agent in rats.
With the help of Caitlin Inc., a company set up to produce and market the technology, Lin hopes to build enough of the
nanosphere catalysts over the next 18 months to augment biodiesel production from a lab scale to a plant scale of 300 gallons per day.