The gut microflora breaks down naringin to its aglycon form
naringenin in the intestine, where it is then absorbed from the gut and has a stronger anti-oxidant effect than naringin itself [1].
Synergistic enhancement of the anti-cancer effects of naringenin can be obtained by combining it with either curcumin83 or vitamin E, 84 and one study reports that nano - encapsulated naringenin exhibits «significantly higher» antioxidant and anticancer properties than
naringenin in free form.86
Not exact matches
It has 2 grams of fiber, the equivalent of 2 teaspoons of sugar, and a whole day's worth of vitamin C. Mandarins are valuable sources of flavonoid antioxidants like
naringenin, naringin, hesperetin, vitamin - A, carotenes, xanthins, and lutein;
in fact, many times higher than
in the oranges.
Included
in the list of cabbage flavonoids are the following anti-inflammatory compounds: artemetin, betanidin, butein, equol, hydroxyflavone, kaempferol, luteolin, malvidin,
naringenin, pelargonodin, purpurogalin, quercitol, and tetrahydrochalcone.
It contains high amounts of the flavonoids (−)- epicatechin (EC), (+)- catechin and their dimers procyanidins B2 (PB2) and B1, and other polyphenols such as quercetin, isoquercitrin (quercetin 3 - O - glucoside), quercetin 3 - O - arabinose, hyperoside (quercetin 3 - O - galactoside),
naringenin, luteolin and apigenin have also been found
in minor quantities.
Naringin and
naringenin supplementation has proven to be effective for the treatment of metabolic syndrome and obesity
in animal models [1].
Compounds
in grapefruit juice, including
naringenin, slow the normal detoxification and metabolism processes
in the intestines and liver, which hinders the body's ability to breakdown and eliminate these drugs.
Some of the flavonoids such as
naringenin which is concentrated
in citrus fruit and
in particular grapefruit strongly inhibit CYP.
First, grapefruit contains a compound called
naringenin, which inactivates an enzyme (cytochrome P450 3A4)
in the small intestine that metabolizes statin drugs.
Question for you: you recommend grapefruit as a detox boosting food, but a primary flavonoid
in grapefruit (
naringenin) inhibits the liver's ability to detox; specifically phase I detoxification.
Twenty potent antioxidant flavonoids were identified
in almond skins
in this study, some of which are well known as major contributors to the health benefits derived from other foods, such as the catechins found
in green tea, and
naringenin, which is found
in grapefruit.
This study identified 9 new antioxidants
in almonds, including
naringenin and vanillic acid.
You could also argue that the nut's complex antioxidant profile gives almond oil big potential for unknown benefits, but
naringenin, vanillic acid and their cousins are mostly concentrated
in the skin and never make their way to the oil.
In lab studies,
naringenin inhibits enzymes that activate carcinogens and the aromatase enzyme that stimulates estrogen production.
One of them,
naringenin, has been shown to inhibit growth of breast cancer and other cancer cells
in laboratory studies.
Leonardi, T., et al., Apigenin and
naringenin suppress colon carcinogenesis through the aberrant crypt stage
in azoxymethane - treated rats.
In animal and cell studies, grapefruit powder, limonin and
naringenin decrease growth and increase self - destruction of colon, mouth, skin, lung, breast and stomach cancers.