The researchers performed genome - wide analysis of
nasal epithelial cells collected from children experiencing acute asthma exacerbation.
Human
nasal epithelial cells, cultured on a microchip, react to air pollutants just like they would in the upper airway.
A membrane — designed to support the cultivation and differentiation of human
nasal epithelial stem cells — was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.
«With Rudolph,» Farber says, «the coral DNA got inserted into a gene that is normally expressed in
the nasal epithelial cells, the cells of his nose.
Not exact matches
As a comparison group, they retrieved pediatric
nasal airway
epithelial cultures from a study that looked at genomic DNA methylation patterns and gene expression in 36 children with persistent atopic asthma compared with 36 heathy children.