Associating proportional changes in the viral titre of nasal washes in the ferret study [16] with proportional changes in viral titres in nasal sprays in the human challenge studies [39], and taking the household SAR to approximate
natural infectivity, we estimated the antipyretic - induced individual transmission enhancement factor fi using equation S22 in the electronic supplementary material.
The limited
infectivity of persisting non-cultivable B. burgdorferi has no biological significance for the
natural enzootic cycle of B. burgdorferi, but it remains to be determined if they have significance in the post-treatment host.