The nature of amyloid disease makes it difficult to qualify for most life insurance policies because amyloid disease can affect so many different parts of the body in may «unpredictable» ways.
(NaturalHealth365) Today, we reveal the true
nature of amyloid plaque and its connection to Alzheimer's disease.
Not exact matches
Four
of the seven peptides made
amyloids that could break down organic molecules called esters (
Nature Chemistry, doi.org/rxf).
But the
nature of these dimers has been hotly debated because it was not known whether the two beta -
amyloid molecules that form the dimer were linked by a chemical bond or not.
Now Filippo Rossi
of the University
of Verona and his colleagues elsewhere in Italy and in Philadelphia have identified a mechanism to explain how β -
amyloid and the brain's microglia act together to kill nerve cells (
Nature, vol 374, p 647).
The drug halved the rate
of Alzheimer's cognitive decline but was overlooked when the beta -
amyloid theory
of the disease became dominant (
Nature Communications, DOI: 10.1038 / ncomms7760).
The light seemed to boost the activity
of cells that clear
amyloid, and cut
amyloid production (
Nature, DOI: 10.1038 /
nature20587).
And more direct evidence for its role in making plaques is the fact that cells produced more beta
amyloid if they contained certain mutated forms
of nicastrin, the researchers report in the 7 September issue
of Nature.
Researchers from Chalmers University
of Technology recently unveiled an unexpected discovery about
amyloid in an article published in the
Nature Photonics journal.
Additional experiments with cultured cells suggested that the mutation interferes with one
of the enzymes that breaks down the APP protein and causes a 40 % reduction in β
amyloid formation, Stefansson and colleagues report online today in
Nature.
Nature - http://www.
nature.com/nsu/040105/040105-6.html Researchers may have pinpointed the cause
of Alzheimer's disease - a rogue protein called
amyloid beta (A?)
«These findings give us some fundamental insights in how
amyloid fibers form,» says Whitehead Member Susan Lindquist, lead scientist in the research team whose results will be published in the June 9 issue
of the journal
Nature.
The
nature of those plaques finally came into focus in 1984, when George Glenner, a research scientist at the University
of California, San Diego, identified the peptide called
amyloid - beta and hypothesized that Alzheimer's was caused by «amyloidosis»
of the brain, a process in which insoluble forms
of an
amyloid protein accumulate.
In a recent
Nature News article, Boer Deng highlights an emerging idea in the Alzheimerâ $ ™ s field that may partly explain why: not all forms
of aggregated
amyloid - beta are the same.
In the October 19, 2006, issue
of Nature (available online Oct. 11), the researchers describe the structures
of insulin - degrading enzyme (IDE) in complex with four
of the proteins it digests: insulin,
amyloid - beta, amylin and glucagon.