An associated variant
near a gene may have nothing to do with that gene.
Although the teams took very different approaches to solve the mystery of how those limbs vanished, both came up with similar results: Mutations in DNA located
near a gene key to limb formation keep that gene from ever turning on, they report today.
The other big hit, the team reports in the journal PLoS Genetics, was a variant
near a gene called AHR, which regulates how CYP1A2 is expressed.
Subsequent tests revealed that the retrovirus used to ferry the corrective gene into the DNA of blood - making cells in the bone marrow had lodged in or
near a gene that regulates T cells, possibly prompting their uncontrolled growth.
For example, domestication had seemingly altered 13 places
near a gene called SOX2, which helps maintain cells destined to become part of the nervous system.
The variant lies
near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.
The study adds to evidence that gene editing may need to be adapted to each patient's genome, to ensure there aren't variants in DNA sequence in or
near the gene being targeted that would throw off the technology.
The second most significantly associated region is
near the gene MFSD12.
Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated
near the gene under their control.
The researchers found, for example, that extraversion was associated with variants in the gene WSCD2 and
near gene PCDH15; neuroticism was associated with variants on chromosome 8p23.1 and gene L3MBTL2.
His team found a variant
near the gene associated with earlier breast development in girls and, in boys, earlier voice - breaking.
McRae and colleagues found that the genetic variants associated all lie in or
near genes that encode so - called odorant or olfactory receptors.
Although they have not been implicated directly in pancreatic function, genomewide association studies have linked the presence of a mutation
near the genes to an impaired ability to properly manage fasting blood - glucose levels.
A yeast retrotransposon called Ty3, the researchers have found, is especially judicious: it always inserts itself in safe places, outside genes rather than inside them, and only
near genes of which a yeast cell has many copies.
Of particular interest was that four of the 10 sites most strongly linked to the AOSI scores were located
near genes linked to Prader - Willi syndrome, a genetic disorder that shares some behavioral symptoms with autism.
Further analysis showed that wild type HIV - 1 tends to integrate itself into or
near genes affecting CD4 + T cell activation and metabolism more frequently than does the mutant strain.
Several different variants are all uniquely associated with pigmentation
near these genes, and variants in these genes have been associated with pigmentation in animals.
In this paper, we report that HIV - 1 prefers to integrate into o
near genes that control such changes in CD4 + T cells so that the virus is better able to remain coupled to the CD4 + T cell status.
Many of the regions are
near genes known to be involved in brain development and function.
He and Duke graduate student Lomax Boyd scanned the genomic databases and combed the scientific literature for enhancers that were different between humans and chimps and that were
near genes that play a role in the brain.
Many cluster around sets of genes associated with growth, including 21 variants found in or
near genes that regulate the building of bone.
The other finding was of a variant
near genes for several so - called semaphorins, proteins that guide developing nerve cells as they grow toward their final targets.
Often, the methyl groups were missing
near genes involved in metabolism that may play a role in obesity and diabetes.
One surprising finding from the study co-led by Johns Hopkins, Ehret says, was that many of the new sites identified were
near genes that are active in cells that line the inside of blood vessels, suggesting those cells are somehow involved directly in blood pressure control.
The cells, or clones, that multiplied in these CGD patients had gene insertions in three locations
near genes involved in cell proliferation.
They found CAD - related SNPs in or
near genes governing such functions as stickiness of cells, coagulation and inflammation, and the differentiation of smooth muscle cells.
Interestingly, Human DNA gains and losses and mouse DNA losses all occurred
near genes involved in fundamental cellular / metabolic processes.
However, for some mouse DNA losses the case may be different, as in the mm10 genomic background they mostly occurred
near genes involved in developmental processes.
These genetic variations were found in regions of the DNA that were
near genes involved in Parkinson's disease and other brain disorders.
Distribution of individual CpG sites located in or
near genes that exhibit differential expression in T2D discordant twins, and that show an inverse (I) or positive (J) relationship between DNA methylation and mRNA expression in the discordant twins in relation to CpG island regions.
Someone on the Twitter feed rightfully reminded us that GWAS hits should generally not be reported along with the «
nearest gene» — a trend that tends to pollute the scientific literature.
Distributions of individual sites that exhibit differential DNA methylation in adipose tissue from 28 diabetic compared with 28 nondiabetic unrelated subjects in relation to
nearest gene regions (H) and CpG island regions (I).
To evaluate the global human methylome in adipose tissue, we calculated the average level of methylation for all sites divided into groups based on either their location in relation to
the nearest gene (Fig. 2A) or the location in relation to CpG islands (Fig. 2B)(24).
Many HARs are located
near genes that control fundamental developmental processes, 9 so their altered regulatory function could have profound effects on human biology.
As reported today in Nature, the team deleted ten limb enhancers
near genes essential for limb development.
Stewart discovered that the histone modifications that poise embryonic stem cell - specific genes for activation are also found on the histones
near genes involved in regeneration, putting them into a ready - to - go state.
Not exact matches
Now that the barrier of editing
genes in the hospital setting has been broken, these companies and more have pipelines of
gene - editing innovation coming to a hospital
near you in the next few years, as clinical trials are approved and new ways to cure formerly incurable diseases go mainstream in our lifetimes.
Whether you think Zayner is a prophet or a crackpot, the point is that you should get ready for
gene editing and
gene therapy coming to a hospital
near you.
In the futuristic world of Star Trek,
Gene Roddenberry and his successors weaved together a series that takes a
near utopian look at future humans.
In his words, «The primary problem is not to provide the public with the knowledge of how far it is to the
nearest star and what
genes are made of....
Experiments proved that Heat Shock Factor 1 (HSF1), a sort of protective switch against some types of cellular stress, could bind to the TTR
gene's promoter (a segment of DNA
near the TTR
gene).
Genetic variations most strongly associated with high scores were found
near the GATA2
gene — involved in the development of inner ear hair cells and the inferior colliculus.
Wherever there is a significant increase in sharing, Sanders plans to look at the
genes that can be found
near that particular marker.
C. renhardtii had similar
genes near but outside its MT. Like so much else, it seems sex cells are all about location, location, location (Science, vol 328, p 351).
After
gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence
near the OCA2
gene.
(
Gene Shoemaker died while the probe was en route, and NASA renamed it
NEAR - Shoemaker.)
Analysis of a specific
gene has now demonstrated that although bats live in air and dolphins in water, where sound travels five times faster, they independently evolved a
near - identical
gene that allows them to accept high - frequency sound in the ear — vital for sonar.
Barroso spent his first year at GSK's Biopharmaceuticals Centre of Excellence for Drug Discovery
near London looking at the use of adenoviruses in
gene - transfer therapy.
But to my mind that is not how it has turned out — rather the reverse with a
near equivalence of a modest 20,000
genes across the vast range of organismic complexity from the millimetre - long Caenorhabditis elegans to the 60 - trillion - celled Homo sapiens.
«What happened here was most likely an increase in population size, with increasing fecundity, and higher levels of mobility and
gene flow so that, over time, Neolithic
Near Eastern villages became more cosmopolitan, and this eventually triggered expansion into Europe.»