Brachytherapy is a type of cancer treatment in which radioactive implants are inserted directly into the
tissue near the tumor site.
In an ovarian cancer model, the group saw that placing T
cells near tumors caused them to shrink — but again, intravenously delivered T cells did not.
«Using the same amount of CDN, the STINGel approach allows the concentration of
CDN near the tumor to remain much higher for long periods of time.»
The result is an immune system less able to fight the virus, and, if the virus causes cancer, a «microenvironment»
near the tumor in which the immune system is suppressed.
«In extreme cases, if the dose is too high radiation can modify the cellular structure and generate alteration in the cells of organs
found near the tumor, this causes them to lose their functions,» said Massillon, who was honored for her research with the IUPAP Young Scientist Prize 2015 awarded by the International Union of Pure and Applied Physics.
Angiogenesis - inhibitor researcher Judah Folkman of Harvard Medical School says doctors might not have to operate at all if they could inject the
capsules near the tumor.
«Our original hypothesis was that cancer cells were modifying their metabolism based on communications they were receiving from cells in the
microenvironment near the tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.
Dissolving polymer wafers soaked with chemotherapy drugs were being
implanted near tumors, but Stephan knew that T cells, which are capable of «squeezing throughout the entire tumor bed,» would be more effective than drugs, which can only penetrate a millimeter or so into tissue.
The researchers found that the microglia within the optic tumors from female mice were activated, and the
neurons near the tumors were damaged.
The same results suggest the Tregs and killer T cells may in fact compete for dendritic
cells near tumors, say the authors.
Some of these treatments may be contraindicated in some situations — for example, massage should never be done on or
near a tumor.
Radiation Radiation therapy delivers very strong X-ray beams to a tumor in an effort to kill the tumor cells, but like chemotherapy, it can also harm healthy tissue
near the tumor.